Zhang Z - Search Results

1

Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.

Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, Chapman KT, Yang L, Xiong Y. Zhou C, et al. Among authors: zhang z. J Med Chem. 2010 Oct 14;53(19):7251-63. doi: 10.1021/jm101013m. J Med Chem. 2010. PMID: 20857914

2

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

Blizzard TA, DiNinno F, Morgan JD 2nd, Chen HY, Wu JY, Gude C, Kim S, Chan W, Birzin ET, Tien Yang Y, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: zhang z. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3861-4. doi: 10.1016/j.bmcl.2004.05.074. Bioorg Med Chem Lett. 2004. PMID: 15225685

3

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.

Blizzard TA, DiNinno F, Morgan JD 2nd, Wu JY, Chen HY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: zhang z. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3865-8. doi: 10.1016/j.bmcl.2004.05.073. Bioorg Med Chem Lett. 2004. PMID: 15225686

4

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.

Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML. Blizzard TA, et al. Among authors: zhang z. Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. doi: 10.1016/j.bmcl.2004.10.036. Bioorg Med Chem Lett. 2005. PMID: 15582421

5

Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.

Kim S, Wu JY, Zhang Z, Tang W, Doss GA, Dean BJ, Dininno F, Hammond ML. Kim S, et al. Among authors: zhang z. Org Lett. 2005 Feb 3;7(3):411-4. doi: 10.1021/ol047741f. Org Lett. 2005. PMID: 15673252

6

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA. Doss GA, et al. Among authors: zhang z. Chem Res Toxicol. 2005 Feb;18(2):271-6. doi: 10.1021/tx049711r. Chem Res Toxicol. 2005. PMID: 15720132

7

The Importance of Tracking "Missing" Metabolites: How and Why?

Wang S, Ballard TE, Christopher LJ, Foti RS, Gu C, Khojasteh SC, Liu J, Ma S, Ma B, Obach RS, Schadt S, Zhang Z, Zhang D. Wang S, et al. Among authors: zhang d, zhang z. J Med Chem. 2023 Dec 14;66(23):15586-15612. doi: 10.1021/acs.jmedchem.3c01293. Epub 2023 Sep 28. J Med Chem. 2023. PMID: 37769129 Review.

8

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: zhang z. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

9

Metabolite identification and profiling in drug design: current practice and future directions.

Zhang Z, Zhu M, Tang W. Zhang Z, et al. Curr Pharm Des. 2009;15(19):2220-35. doi: 10.2174/138161209788682460. Curr Pharm Des. 2009. PMID: 19601824 Review.

10

In vitro bioactivation of a selective estrogen receptor modulator (2S,3R)-(+)-3-(3-hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in liver microsomes: formation of adenine adducts.

Li Y, Doss GA, Li Y, Chen Q, Tang W, Zhang Z. Li Y, et al. Among authors: zhang z. Chem Res Toxicol. 2012 Nov 19;25(11):2368-77. doi: 10.1021/tx3002466. Epub 2012 Oct 9. Chem Res Toxicol. 2012. PMID: 22998117

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