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Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.
Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Alvarez A, et al. Among authors: munoz fj. J Neurosci. 1998 May 1;18(9):3213-23. doi: 10.1523/JNEUROSCI.18-09-03213.1998. J Neurosci. 1998. PMID: 9547230 Free PMC article.
Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis.
Ill-Raga G, Tajes M, Busquets-García A, Ramos-Fernández E, Vargas LM, Bosch-Morató M, Guivernau B, Valls-Comamala V, Eraso-Pichot A, Guix FX, Fandos C, Rosen MD, Rabinowitz MH, Maldonado R, Alvarez AR, Ozaita A, Muñoz FJ. Ill-Raga G, et al. Among authors: munoz fj. Antioxid Redox Signal. 2015 May 20;22(15):1295-307. doi: 10.1089/ars.2014.6080. Epub 2015 Mar 25. Antioxid Redox Signal. 2015. PMID: 25706765
Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.
Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, Altafaj X, Ozaita A, Alvarez A, Vicente R, Valverde MA, Muñoz FJ. Ramos-Fernández E, et al. Among authors: munoz fj. Oncotarget. 2016 Sep 13;7(37):58876-58892. doi: 10.18632/oncotarget.11417. Oncotarget. 2016. PMID: 27557499 Free PMC article.
Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus: From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease.
Picón-Pagès P, Bonet J, García-García J, Garcia-Buendia J, Gutierrez D, Valle J, Gómez-Casuso CES, Sidelkivska V, Alvarez A, Perálvarez-Marín A, Suades A, Fernàndez-Busquets X, Andreu D, Vicente R, Oliva B, Muñoz FJ. Picón-Pagès P, et al. Among authors: munoz fj. Comput Struct Biotechnol J. 2019 Jun 26;17:963-971. doi: 10.1016/j.csbj.2019.06.017. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 31360335 Free PMC article.
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α.
Picón-Pagès P, Gutiérrez DA, Barranco-Almohalla A, Crepin G, Tajes M, Ill-Raga G, Guix FX, Menéndez S, Arumí-Uría M, Vicente R, Álvarez AR, Muñoz FJ. Picón-Pagès P, et al. Among authors: munoz fj. Oxid Med Cell Longev. 2020 Sep 19;2020:2739459. doi: 10.1155/2020/2739459. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33014268 Free PMC article.
Amyloid β-Peptide Causes the Permanent Activation of CaMKIIα through Its Oxidation.
Picón-Pagès P, Fanlo-Ucar H, Herrera-Fernández V, Ausellé-Bosch S, Galera-López L, Gutiérrez DA, Ozaita A, Álvarez AR, Oliva B, Muñoz FJ. Picón-Pagès P, et al. Among authors: munoz fj. Int J Mol Sci. 2022 Dec 2;23(23):15169. doi: 10.3390/ijms232315169. Int J Mol Sci. 2022. PMID: 36499491 Free PMC article.
218 results