Chiang MY - Search Results

1

Notch dimerization is required for leukemogenesis and T-cell development.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Liu H, et al. Among authors: chiang my. Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8. Genes Dev. 2010. PMID: 20935071 Free PMC article.

2

Cancer genetics: activated notch takes center stage in T-cell leukemogenesis.

Chiang MY, Pear WS. Chiang MY, et al. Eur J Hum Genet. 2005 Apr;13(4):393-5. doi: 10.1038/sj.ejhg.5201380. Eur J Hum Genet. 2005. PMID: 15702128 Review. No abstract available.

3

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Yashiro-Ohtani Y, et al. Among authors: chiang my. Genes Dev. 2009 Jul 15;23(14):1665-76. doi: 10.1101/gad.1793709. Genes Dev. 2009. PMID: 19605688 Free PMC article.

4

Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia.

Liu H, Chiang MY, Pear WS. Liu H, et al. Among authors: chiang my. Int J Hematol. 2011 Aug;94(2):118-125. doi: 10.1007/s12185-011-0899-3. Epub 2011 Aug 5. Int J Hematol. 2011. PMID: 21814881 Review.

5

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Chiang MY, Wang Q, Gormley AC, Stein SJ, Xu L, Shestova O, Aster JC, Pear WS. Chiang MY, et al. Blood. 2016 Nov 3;128(18):2229-2240. doi: 10.1182/blood-2016-01-692855. Epub 2016 Sep 26. Blood. 2016. PMID: 27670423 Free PMC article.

6

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Chiang MY, et al. Mol Cell Biol. 2006 Aug;26(16):6261-71. doi: 10.1128/MCB.02478-05. Mol Cell Biol. 2006. PMID: 16880534 Free PMC article.

7

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS. Chiang MY, et al. J Clin Invest. 2008 Sep;118(9):3181-94. doi: 10.1172/JCI35090. J Clin Invest. 2008. PMID: 18677410 Free PMC article.

8

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Chiang MY, Shestova O, Xu L, Aster JC, Pear WS. Chiang MY, et al. Blood. 2013 Feb 7;121(6):905-17. doi: 10.1182/blood-2012-03-416503. Epub 2012 Oct 31. Blood. 2013. PMID: 23115273 Free PMC article.

9

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Ashworth TD, et al. Among authors: chiang my. Blood. 2010 Dec 16;116(25):5455-64. doi: 10.1182/blood-2010-05-286328. Epub 2010 Sep 17. Blood. 2010. PMID: 20852131 Free PMC article.

10

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP. Giambra V, et al. Among authors: chiang my. Nat Med. 2012 Nov;18(11):1693-8. doi: 10.1038/nm.2960. Epub 2012 Oct 21. Nat Med. 2012. PMID: 23086478 Free PMC article.

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