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The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.
Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ. Belyaev ND, et al. Among authors: kellett ka. J Biol Chem. 2010 Dec 31;285(53):41443-54. doi: 10.1074/jbc.M110.141390. Epub 2010 Oct 20. J Biol Chem. 2010. PMID: 20961856 Free PMC article.
Prion protein and Alzheimer disease.
Kellett KA, Hooper NM. Kellett KA, et al. Prion. 2009 Oct-Dec;3(4):190-4. doi: 10.4161/pri.3.4.9980. Epub 2009 Oct 2. Prion. 2009. PMID: 19887909 Free PMC article. Review.
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM. Griffiths HH, et al. Among authors: kellett ka. J Biol Chem. 2011 Sep 23;286(38):33489-500. doi: 10.1074/jbc.M111.278556. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795680 Free PMC article.
31 results