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Targeting the correct HDAC(s) to treat cognitive disorders.
Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Fischer A, et al. Among authors: tsai lh. Trends Pharmacol Sci. 2010 Dec;31(12):605-17. doi: 10.1016/j.tips.2010.09.003. Epub 2010 Oct 25. Trends Pharmacol Sci. 2010. PMID: 20980063 Review.
A hippocampal Cdk5 pathway regulates extinction of contextual fear.
Sananbenesi F, Fischer A, Wang X, Schrick C, Neve R, Radulovic J, Tsai LH. Sananbenesi F, et al. Among authors: tsai lh. Nat Neurosci. 2007 Aug;10(8):1012-9. doi: 10.1038/nn1943. Epub 2007 Jul 15. Nat Neurosci. 2007. PMID: 17632506 Free PMC article.
The potential of HDAC inhibitors as cognitive enhancers.
Gräff J, Tsai LH. Gräff J, et al. Among authors: tsai lh. Annu Rev Pharmacol Toxicol. 2013;53:311-30. doi: 10.1146/annurev-pharmtox-011112-140216. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294310 Review.
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S. Chung CY, et al. Among authors: tsai lh. Science. 2013 Nov 22;342(6161):983-7. doi: 10.1126/science.1245296. Epub 2013 Oct 24. Science. 2013. PMID: 24158904 Free PMC article.
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway.
Rei D, Mason X, Seo J, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH. Rei D, et al. Among authors: tsai lh. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7291-6. doi: 10.1073/pnas.1415845112. Epub 2015 May 20. Proc Natl Acad Sci U S A. 2015. PMID: 25995364 Free PMC article.
426 results