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Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.
Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, Gertner MJ, Woo NH, Tranfaglia MR, Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM. Choi CH, et al. Among authors: tranfaglia mr. Brain Res. 2011 Mar 22;1380:106-19. doi: 10.1016/j.brainres.2010.11.032. Epub 2010 Nov 12. Brain Res. 2011. PMID: 21078304 Free PMC article.
PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
Choi CH, Schoenfeld BP, Weisz ED, Bell AJ, Chambers DB, Hinchey J, Choi RJ, Hinchey P, Kollaros M, Gertner MJ, Ferrick NJ, Terlizzi AM, Yohn N, Koenigsberg E, Liebelt DA, Zukin RS, Woo NH, Tranfaglia MR, Louneva N, Arnold SE, Siegel SJ, Bolduc FV, McDonald TV, Jongens TA, McBride SM. Choi CH, et al. Among authors: tranfaglia mr. J Neurosci. 2015 Jan 7;35(1):396-408. doi: 10.1523/JNEUROSCI.1356-12.2015. J Neurosci. 2015. PMID: 25568131 Free PMC article.
Advances in the treatment of fragile X syndrome.
Hagerman RJ, Berry-Kravis E, Kaufmann WE, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Hessl D, Visootsak J, Picker J, Gane L, Tranfaglia M. Hagerman RJ, et al. Pediatrics. 2009 Jan;123(1):378-90. doi: 10.1542/peds.2008-0317. Pediatrics. 2009. PMID: 19117905 Free PMC article. Review.
Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.
Westmark CJ, Westmark PR, O'Riordan KJ, Ray BC, Hervey CM, Salamat MS, Abozeid SH, Stein KM, Stodola LA, Tranfaglia M, Burger C, Berry-Kravis EM, Malter JS. Westmark CJ, et al. PLoS One. 2011;6(10):e26549. doi: 10.1371/journal.pone.0026549. Epub 2011 Oct 26. PLoS One. 2011. PMID: 22046307 Free PMC article.
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.
Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchison J, Snape M, Tranfaglia M, Nguyen DV, Hagerman R. Berry-Kravis E, et al. J Med Genet. 2009 Apr;46(4):266-71. doi: 10.1136/jmg.2008.063701. Epub 2009 Jan 6. J Med Genet. 2009. PMID: 19126569 Free PMC article. Clinical Trial.
A novel combination treatment for fragile X syndrome predicted using computational methods.
Chadwick W, Angulo-Herrera I, Cogram P, Deacon RJM, Mason DJ, Brown D, Roberts I, O'Donovan DJ, Tranfaglia MR, Guilliams T, Thompson NT. Chadwick W, et al. Among authors: tranfaglia mr. Brain Commun. 2024 Jan 15;6(1):fcad353. doi: 10.1093/braincomms/fcad353. eCollection 2024. Brain Commun. 2024. PMID: 38226317 Free PMC article.
15 results