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Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.
Li D, Geng K, Hao Y, Gu J, Kumar S, Olson AT, Kuismi CC, Kim HM, Pan Y, Sherman F, Williams AM, Li Y, Li F, Chen T, Thakurdin C, Ranieri M, Meynardie M, Levin DS, Stephens J, Chafitz A, Chen J, Donald-Paladino MS, Powell JM, Zhang ZY, Chen W, Ploszaj M, Han H, Gu S, Zhang T, Hu B, Nacev BA, Kaiza ME, Berger AH, Wang X, Li J, Sun X, Liu Y, Zhang X, Bruno TC, Gray NS, Nabet B, Wong KK, Zhang H. Li D, et al. Among authors: wong kk. J Clin Invest. 2024 Dec 24:e174249. doi: 10.1172/JCI174249. Online ahead of print. J Clin Invest. 2024. PMID: 39718828
Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target.
Wang H, Tang S, Wu Q, He Y, Zhu W, Xie X, Qin Z, Wang X, Zhou S, Yao S, Xu X, Guo C, Tong X, Han S, Chou YH, Wang Y, Wong KK, Yang CG, Chen L, Hu L, Ji H. Wang H, et al. Among authors: wong kk. Natl Sci Rev. 2024 Nov 7;11(12):nwae392. doi: 10.1093/nsr/nwae392. eCollection 2024 Dec. Natl Sci Rev. 2024. PMID: 39687207 Free PMC article.
Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C.
Maciag AE, Stice JP, Wang B, Sharma AK, Chan AH, Lin K, Singh D, Dyba M, Yang Y, Setoodeh S, Smith BP, Ju JH, Jeknic S, Rabara D, Zhang Z, Larsen EK, Esposito D, Denson JP, Ranieri M, Meynardie M, Mehdizadeh S, Alexander PA, Abreu Blanco M, Turner DM, Xu R, Lightstone FC, Wong KK, Stephen AG, Wang K, Simanshu DK, Sinkevicius KW, Nissley DV, Wallace E, McCormick F, Beltran PJ. Maciag AE, et al. Among authors: wong kk. Cancer Discov. 2024 Dec 6. doi: 10.1158/2159-8290.CD-24-0840. Online ahead of print. Cancer Discov. 2024. PMID: 39642212
Lung allograft dysbiosis associates with immune response and primary graft dysfunction.
Nelson NC, Wong KK, Mahoney IJ, Malik T, Rudym D, Lesko MB, Qayum S, Lewis TC, Chang SH, Chan JCY, Geraci TC, Li Y, Pamar P, Schnier J, Singh R, Collazo D, Chang M, Kyeremateng Y, McCormick C, Borghi S, Patel S, Darawshy F, Barnett CR, Sulaiman I, Kugler MC, Brosnahan SB, Singh S, Tsay JJ, Wu BG, Pass HI, Angel LF, Segal LN, Natalini JG. Nelson NC, et al. Among authors: wong kk. J Heart Lung Transplant. 2024 Nov 17:S1053-2498(24)01946-6. doi: 10.1016/j.healun.2024.11.006. Online ahead of print. J Heart Lung Transplant. 2024. PMID: 39561864
1,811 results