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A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).
Shaltiel-Karyo R, Frenkel-Pinter M, Rockenstein E, Patrick C, Levy-Sakin M, Schiller A, Egoz-Matia N, Masliah E, Segal D, Gazit E. Shaltiel-Karyo R, et al. Among authors: egoz matia n. J Biol Chem. 2013 Jun 14;288(24):17579-88. doi: 10.1074/jbc.M112.434787. Epub 2013 May 1. J Biol Chem. 2013. PMID: 23637226 Free PMC article.