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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE. Boeddrich A, et al. Among authors: tzvetkov n. EMBO J. 2006 Apr 5;25(7):1547-58. doi: 10.1038/sj.emboj.7601043. Epub 2006 Mar 9. EMBO J. 2006. PMID: 16525503 Free PMC article.
Mutations in p97/VCP induce unfolding activity.
Rothballer A, Tzvetkov N, Zwickl P. Rothballer A, et al. Among authors: tzvetkov n. FEBS Lett. 2007 Mar 20;581(6):1197-201. doi: 10.1016/j.febslet.2007.02.031. Epub 2007 Feb 28. FEBS Lett. 2007. PMID: 17346713 Free article.
71 results