Shao L - Search Results

1

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.

Shao L, Wang F, Malcolm SC, Ma J, Hewitt MC, Campbell UC, Bush LR, Spicer NA, Engel SR, Saraswat LD, Hardy LW, Koch P, Schreiber R, Spear KL, Varney MA. Shao L, et al. Bioorg Med Chem. 2011 Jan 1;19(1):663-76. doi: 10.1016/j.bmc.2010.10.034. Epub 2010 Oct 21. Bioorg Med Chem. 2011. PMID: 21093273

2

Derivatives of tramadol for increased duration of effect.

Shao L, Abolin C, Hewitt MC, Koch P, Varney M. Shao L, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):691-4. doi: 10.1016/j.bmcl.2005.10.024. Epub 2005 Oct 27. Bioorg Med Chem Lett. 2006. PMID: 16257206

3

In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.

Shao L, Hewitt M, Jerussi TP, Wu F, Malcolm S, Grover P, Fang K, Koch P, Senanayake C, Bhongle N, Ribe S, Bakale R, Currie M. Shao L, et al. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1674-80. doi: 10.1016/j.bmcl.2008.01.051. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18242987

4

mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).

Shao L, Wang F, Hewitt MC, Barberich TJ. Shao L, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. doi: 10.1016/j.bmcl.2009.08.016. Epub 2009 Aug 8. Bioorg Med Chem Lett. 2009. PMID: 19700325

5

The kinetic isotope effect in the search for deuterated drugs.

Shao L, Hewitt MC. Shao L, et al. Drug News Perspect. 2010 Jul-Aug;23(6):398-404. doi: 10.1358/dnp.2010.23.6.1426638. Drug News Perspect. 2010. PMID: 20697607 Free article. Review.

6

Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.

Shao L, Ma J, Wang F, Malcolm SC, Hewitt MC, Campbell UC, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):520-3. doi: 10.1016/j.bmcl.2010.10.086. Epub 2010 Oct 28. Bioorg Med Chem Lett. 2011. PMID: 21095126

7

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. doi: 10.1016/j.bmcl.2011.01.016. Epub 2011 Jan 12. Bioorg Med Chem Lett. 2011. PMID: 21310609

8

Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1434-7. doi: 10.1016/j.bmcl.2011.01.019. Epub 2011 Jan 12. Bioorg Med Chem Lett. 2011. PMID: 21310612

9

Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.

Shao L, Hewitt MC, Malcolm SC, Wang F, Ma J, Campbell UC, Spicer NA, Engel SR, Hardy LW, Jiang ZD, Schreiber R, Spear KL, Varney MA. Shao L, et al. J Med Chem. 2011 Aug 11;54(15):5283-95. doi: 10.1021/jm101312a. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739935

10

Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A.

Burdi DF, Campbell JE, Wang J, Zhao S, Zhong H, Wei J, Campbell U, Shao L, Herman L, Koch P, Jones PG, Hewitt MC. Burdi DF, et al. Among authors: shao l. Bioorg Med Chem Lett. 2015 May 1;25(9):1864-8. doi: 10.1016/j.bmcl.2015.03.050. Epub 2015 Mar 26. Bioorg Med Chem Lett. 2015. PMID: 25863433

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