Johnson SR - Search Results

1

Trends in kinase selectivity: insights for target class-focused library screening.

Posy SL, Hermsmeier MA, Vaccaro W, Ott KH, Todderud G, Lippy JS, Trainor GL, Loughney DA, Johnson SR. Posy SL, et al. Among authors: johnson sr. J Med Chem. 2011 Jan 13;54(1):54-66. doi: 10.1021/jm101195a. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128601

2

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

McDonnell PA, Constantine KL, Goldfarb V, Johnson SR, Sulsky R, Magnin DR, Robl JA, Caulfield TJ, Parker RA, Taylor DS, Adam LP, Metzler WJ, Mueller L, Farmer BT 2nd. McDonnell PA, et al. Among authors: johnson sr. J Med Chem. 2006 Aug 10;49(16):5013-7. doi: 10.1021/jm060360i. J Med Chem. 2006. PMID: 16884313

3

A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.

Johnson SR, Padmanabha R, Vaccaro W, Hermsmeier M, Cacace A, Lawrence M, Dickey J, Esposito K, Pike K, Wong V, Poss M, Loughney D, Tebben A. Johnson SR, et al. J Biomol Screen. 2007 Mar;12(2):276-84. doi: 10.1177/1087057106297826. Epub 2007 Feb 1. J Biomol Screen. 2007. PMID: 17272827

4

Estimation of hERG inhibition of drug candidates using multivariate property and pharmacophore SAR.

Johnson SR, Yue H, Conder ML, Shi H, Doweyko AM, Lloyd J, Levesque P. Johnson SR, et al. Bioorg Med Chem. 2007 Sep 15;15(18):6182-92. doi: 10.1016/j.bmc.2007.06.028. Epub 2007 Jun 14. Bioorg Med Chem. 2007. PMID: 17596950

5

To measure is to know: an approach to CADD performance metrics.

Loughney D, Claus BL, Johnson SR. Loughney D, et al. Among authors: johnson sr. Drug Discov Today. 2011 Jul;16(13-14):548-54. doi: 10.1016/j.drudis.2011.05.003. Epub 2011 May 13. Drug Discov Today. 2011. PMID: 21605697

6

3D matched pairs: integrating ligand- and structure-based knowledge for ligand design and receptor annotation.

Posy SL, Claus BL, Pokross ME, Johnson SR. Posy SL, et al. Among authors: johnson sr. J Chem Inf Model. 2013 Jul 22;53(7):1576-88. doi: 10.1021/ci400201k. Epub 2013 Jul 10. J Chem Inf Model. 2013. PMID: 23809058

7

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

Tokarski JS, Zupa-Fernandez A, Tredup JA, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson SR, Wu S, Edavettal SC, Hong Y, Witmer MR, Elkin LL, Blat Y, Pitts WJ, Weinstein DS, Burke JR. Tokarski JS, et al. Among authors: johnson sr. J Biol Chem. 2015 Apr 24;290(17):11061-74. doi: 10.1074/jbc.M114.619502. Epub 2015 Mar 11. J Biol Chem. 2015. PMID: 25762719 Free PMC article.

8

Approaches for machine learning intermolecular interaction energies and application to energy components from symmetry adapted perturbation theory.

Metcalf DP, Koutsoukas A, Spronk SA, Claus BL, Loughney DA, Johnson SR, Cheney DL, Sherrill CD. Metcalf DP, et al. Among authors: johnson sr. J Chem Phys. 2020 Feb 21;152(7):074103. doi: 10.1063/1.5142636. J Chem Phys. 2020. PMID: 32087645

9

MDFit: automated molecular simulations workflow enables high throughput assessment of ligands-protein dynamics.

Brueckner AC, Shields B, Kirubakaran P, Suponya A, Panda M, Posy SL, Johnson S, Lakkaraju SK. Brueckner AC, et al. J Comput Aided Mol Des. 2024 Jul 17;38(1):24. doi: 10.1007/s10822-024-00564-2. J Comput Aided Mol Des. 2024. PMID: 39014286

10

Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.

Kim SH, Constantine KL, Duke GJ, Goldfarb V, Hunt JT, Johnson S, Kish K, Klei HE, McDonnell PA, Metzler WJ, Mueller L, Poss MA, Fairchild CR, Bhide RS. Kim SH, et al. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4107-11. doi: 10.1016/j.bmcl.2013.05.052. Epub 2013 May 23. Bioorg Med Chem Lett. 2013. PMID: 23747226

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