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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Figueroa ME, et al. Among authors: delwel r. Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9. Cancer Cell. 2010. PMID: 21130701 Free PMC article.
Mutations in N-ras predominate in acute myeloid leukemia.
Bos JL, Verlaan-de Vries M, van der Eb AJ, Janssen JW, Delwel R, Löwenberg B, Colly LP. Bos JL, et al. Among authors: delwel r. Blood. 1987 Apr;69(4):1237-41. Blood. 1987. PMID: 3103719 Free article.
Leukemic predisposition of pSca-1/Cb2 transgenic mice.
Joosten M, Valk PJ, Jordà MA, Vankan-Berkhoudt Y, Verbakel S, van den Broek M, Beijen A, Löwenberg B, Delwel R. Joosten M, et al. Among authors: delwel r. Exp Hematol. 2002 Feb;30(2):142-9. doi: 10.1016/s0301-472x(01)00779-2. Exp Hematol. 2002. PMID: 11823049 Free article.
193 results