Kumar AP - Search Results

1

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.

Rajendran P, Ong TH, Chen L, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. Rajendran P, et al. Among authors: kumar ap. Clin Cancer Res. 2011 Mar 15;17(6):1425-39. doi: 10.1158/1078-0432.CCR-10-1123. Epub 2010 Dec 3. Clin Cancer Res. 2011. PMID: 21131551

2

Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo.

Kumar AP, Quake AL, Chang MK, Zhou T, Lim KS, Singh R, Hewitt RE, Salto-Tellez M, Pervaiz S, Clément MV. Kumar AP, et al. Cancer Res. 2009 Nov 15;69(22):8636-44. doi: 10.1158/0008-5472.CAN-09-0219. Epub 2009 Nov 3. Cancer Res. 2009. PMID: 19887620

3

Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Tan SM, et al. Among authors: kumar ap. J Pharmacol Exp Ther. 2010 Jul;334(1):285-93. doi: 10.1124/jpet.110.165498. Epub 2010 Apr 8. J Pharmacol Exp Ther. 2010. PMID: 20378717

4

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.

Chua AW, Hay HS, Rajendran P, Shanmugam MK, Li F, Bist P, Koay ES, Lim LH, Kumar AP, Sethi G. Chua AW, et al. Among authors: kumar ap. Biochem Pharmacol. 2010 Nov 15;80(10):1553-62. doi: 10.1016/j.bcp.2010.07.045. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20699088

5

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. Rajendran P, et al. Among authors: kumar ap. Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x. Br J Pharmacol. 2011. PMID: 21198544 Free PMC article.

6

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice.

Shanmugam MK, Rajendran P, Li F, Nema T, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Ho PC, Hui KM, Sethi G. Shanmugam MK, et al. Among authors: kumar ap. J Mol Med (Berl). 2011 Jul;89(7):713-27. doi: 10.1007/s00109-011-0746-2. Epub 2011 Apr 5. J Mol Med (Berl). 2011. PMID: 21465181

7

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.

Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Shanmugam MK, et al. Among authors: kumar ap. Int J Cancer. 2011 Oct 1;129(7):1552-63. doi: 10.1002/ijc.26120. Epub 2011 Jul 20. Int J Cancer. 2011. PMID: 21480220

8

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.

Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Kannaiyan R, et al. Among authors: kumar ap. Br J Pharmacol. 2011 Nov;164(5):1506-21. doi: 10.1111/j.1476-5381.2011.01449.x. Br J Pharmacol. 2011. PMID: 21506956 Free PMC article.

9

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH. Woo CC, et al. Among authors: kumar ap. Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14. Biochem Pharmacol. 2011. PMID: 21679698

10

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.

Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G. Kannaiyan R, et al. Among authors: kumar ap. Apoptosis. 2011 Oct;16(10):1028-41. doi: 10.1007/s10495-011-0629-6. Apoptosis. 2011. PMID: 21786165

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