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iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.
Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. Lim SK, et al. Among authors: feng z. J Biol Chem. 2009 Oct 23;284(43):29746-56. doi: 10.1074/jbc.M109.046805. Epub 2009 Sep 2. J Biol Chem. 2009. PMID: 19726666 Free PMC article.
A designer bleomycin with significantly improved DNA cleavage activity.
Huang SX, Feng Z, Wang L, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B. Huang SX, et al. Among authors: feng z. J Am Chem Soc. 2012 Aug 15;134(32):13501-9. doi: 10.1021/ja3056535. Epub 2012 Aug 6. J Am Chem Soc. 2012. PMID: 22831455 Free PMC article.
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