Gažák R - Search Results

1

Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism.

Gabrielová E, Jabůrek M, Gažák R, Vostálová J, Ježek J, Křen V, Modrianský M. Gabrielová E, et al. Among authors: gazak r. J Bioenerg Biomembr. 2010 Dec;42(6):499-509. doi: 10.1007/s10863-010-9319-2. Epub 2010 Dec 14. J Bioenerg Biomembr. 2010. PMID: 21153691

2

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity--role of individual hydroxyl groups.

Gazák R, Sedmera P, Vrbacký M, Vostálová J, Drahota Z, Marhol P, Walterová D, Kren V. Gazák R, et al. Free Radic Biol Med. 2009 Mar 15;46(6):745-58. doi: 10.1016/j.freeradbiomed.2008.11.016. Epub 2008 Dec 6. Free Radic Biol Med. 2009. PMID: 19138735

3

New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity.

Dzubák P, Hajdúch M, Gazák R, Svobodová A, Psotová J, Walterová D, Sedmera P, Kren V. Dzubák P, et al. Among authors: gazak r. Bioorg Med Chem. 2006 Jun 1;14(11):3793-810. doi: 10.1016/j.bmc.2006.01.035. Epub 2006 Feb 8. Bioorg Med Chem. 2006. PMID: 16466920

4

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II).

Zatloukalová M, Křen V, Gažák R, Kubala M, Trouillas P, Ulrichová J, Vacek J. Zatloukalová M, et al. Among authors: gazak r. Bioelectrochemistry. 2011 Oct;82(2):117-24. doi: 10.1016/j.bioelechem.2011.06.005. Epub 2011 Jun 29. Bioelectrochemistry. 2011. PMID: 21764394

5

Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells.

Karas D, Gažák R, Valentová K, Chambers CS, Pivodová V, Biedermann D, Křenková A, Oborná I, Kuzma M, Cvačka J, Ulrichová J, Křen V. Karas D, et al. Among authors: gazak r. J Nat Prod. 2016 Apr 22;79(4):812-20. doi: 10.1021/acs.jnatprod.5b00905. Epub 2016 Mar 25. J Nat Prod. 2016. PMID: 27015547

6

Oxidised derivatives of silybin and their antiradical and antioxidant activity.

Gazák R, Svobodová A, Psotová J, Sedmera P, Prikrylová V, Walterová D, Kren V. Gazák R, et al. Bioorg Med Chem. 2004 Nov 1;12(21):5677-87. doi: 10.1016/j.bmc.2004.07.064. Bioorg Med Chem. 2004. PMID: 15465345

7

Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.

Plísková M, Vondrácek J, Kren V, Gazák R, Sedmera P, Walterová D, Psotová J, Simánek V, Machala M. Plísková M, et al. Among authors: gazak r. Toxicology. 2005 Nov 5;215(1-2):80-9. doi: 10.1016/j.tox.2005.06.020. Epub 2005 Aug 1. Toxicology. 2005. PMID: 16076518

8

Silybin and silymarin--new and emerging applications in medicine.

Gazák R, Walterová D, Kren V. Gazák R, et al. Curr Med Chem. 2007;14(3):315-38. doi: 10.2174/092986707779941159. Curr Med Chem. 2007. PMID: 17305535 Review.

9

Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study.

Trouillas P, Marsal P, Svobodová A, Vostálová J, Gazák R, Hrbác J, Sedmera P, Kren V, Lazzaroni R, Duroux JL, Walterová D. Trouillas P, et al. Among authors: gazak r. J Phys Chem A. 2008 Feb 7;112(5):1054-63. doi: 10.1021/jp075814h. Epub 2008 Jan 15. J Phys Chem A. 2008. PMID: 18193843

10

A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.

Vrba J, Gažák R, Kuzma M, Papoušková B, Vacek J, Weiszenstein M, Křen V, Ulrichová J. Vrba J, et al. Among authors: gazak r. J Med Chem. 2013 Feb 14;56(3):856-66. doi: 10.1021/jm3013344. Epub 2013 Jan 18. J Med Chem. 2013. PMID: 23294286

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