Busby SA - Search Results

1

A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists.

Vidović D, Busby SA, Griffin PR, Schürer SC. Vidović D, et al. Among authors: busby sa. ChemMedChem. 2011 Jan 3;6(1):94-103. doi: 10.1002/cmdc.201000428. ChemMedChem. 2011. PMID: 21162086 Free PMC article.

2

A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, Southern MR, Griffin PR. Chalmers MJ, et al. Among authors: busby sa. J Biomol Tech. 2007 Sep;18(4):194-204. J Biomol Tech. 2007. PMID: 17916792 Free PMC article.

3

Partial agonists activate PPARgamma using a helix 12 independent mechanism.

Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Bruning JB, et al. Among authors: busby sa. Structure. 2007 Oct;15(10):1258-71. doi: 10.1016/j.str.2007.07.014. Structure. 2007. PMID: 17937915 Free article.

4

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR. Chalmers MJ, et al. Among authors: busby sa. Expert Rev Proteomics. 2011 Feb;8(1):43-59. doi: 10.1586/epr.10.109. Expert Rev Proteomics. 2011. PMID: 21329427 Free PMC article. Review.

5

Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.

Busby SA, Kumar N, Kuruvilla DS, Istrate MA, Conkright JJ, Wang Y, Kamenecka TM, Cameron MD, Roush WR, Burris TP, Griffin PR. Busby SA, et al. ACS Chem Biol. 2011 Jun 17;6(6):618-27. doi: 10.1021/cb100396s. Epub 2011 Mar 17. ACS Chem Biol. 2011. PMID: 21381756 Free PMC article.

6

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: busby sa. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.

7

Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity.

Burris TP, Busby SA, Griffin PR. Burris TP, et al. Among authors: busby sa. Chem Biol. 2012 Jan 27;19(1):51-9. doi: 10.1016/j.chembiol.2011.12.011. Chem Biol. 2012. PMID: 22284354 Free PMC article. Review.

8

Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry.

Chalmers MJ, Busby SA, Pascal BD, He Y, Hendrickson CL, Marshall AG, Griffin PR. Chalmers MJ, et al. Among authors: busby sa. Anal Chem. 2006 Feb 15;78(4):1005-14. doi: 10.1021/ac051294f. Anal Chem. 2006. PMID: 16478090

9

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR. Kumar N, et al. Among authors: busby sa. Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3. Mol Pharmacol. 2010. PMID: 19887649 Free PMC article.

10

Helix 11 dynamics is critical for constitutive androstane receptor activity.

Wright E, Busby SA, Wisecarver S, Vincent J, Griffin PR, Fernandez EJ. Wright E, et al. Among authors: busby sa. Structure. 2011 Jan 12;19(1):37-44. doi: 10.1016/j.str.2010.11.008. Structure. 2011. PMID: 21220114 Free PMC article.

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