A live attenuated chimeric recombinant parainfluenza virus (PIV) encoding the internal proteins of PIV type 3 and the surface glycoproteins of PIV type 1 induces complete resistance to PIV1 challenge and partial resistance to PIV3 challenge.
Tao T, Skiadopoulos MH, Durbin AP, Davoodi F, Collins PL, Murphy BR.
Tao T, et al. Among authors: durbin ap.
Vaccine. 1999 Mar 5;17(9-10):1100-8. doi: 10.1016/s0264-410x(98)00327-2.
Vaccine. 1999.
PMID: 10195620
This was used to recover a fully-viable, recombinant chimeric PIV3-PIV1 virus, termed rPIV3-1, which bears the major protective antigens of PIV1 and is wild type-like with regard to growth in cell culture and in hamsters [Tao T, Durbin AP, Whitehead SS, Davoodi F, C …
This was used to recover a fully-viable, recombinant chimeric PIV3-PIV1 virus, termed rPIV3-1, which bears the major protective antigens of …