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Phase I and pharmacokinetic study of CT-322 (BMS-844203), a targeted Adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin.
Tolcher AW, Sweeney CJ, Papadopoulos K, Patnaik A, Chiorean EG, Mita AC, Sankhala K, Furfine E, Gokemeijer J, Iacono L, Eaton C, Silver BA, Mita M. Tolcher AW, et al. Among authors: furfine e. Clin Cancer Res. 2011 Jan 15;17(2):363-71. doi: 10.1158/1078-0432.CCR-10-1411. Epub 2011 Jan 11. Clin Cancer Res. 2011. PMID: 21224368 Clinical Trial.
Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2.
Mamluk R, Carvajal IM, Morse BA, Wong H, Abramowitz J, Aslanian S, Lim AC, Gokemeijer J, Storek MJ, Lee J, Gosselin M, Wright MC, Camphausen RT, Wang J, Chen Y, Miller K, Sanders K, Short S, Sperinde J, Prasad G, Williams S, Kerbel R, Ebos J, Mutsaers A, Mendlein JD, Harris AS, Furfine ES. Mamluk R, et al. MAbs. 2010 Mar-Apr;2(2):199-208. doi: 10.4161/mabs.2.2.11304. MAbs. 2010. PMID: 20190562 Free PMC article.
A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.
Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, Yamniuk AP, Hosbach J, Brown J, Fitzpatrick E, Gokemeijer J, Morin P, Morse BA, Carvajal IM, Fabrizio D, Wright MC, Das Gupta R, Gosselin M, Cataldo D, Ryseck RP, Doyle ML, Wong TW, Camphausen RT, Cload ST, Marsh HN, Gottardis MM, Furfine ES. Emanuel SL, et al. Among authors: furfine es. MAbs. 2011 Jan-Feb;3(1):38-48. doi: 10.4161/mabs.3.1.14168. Epub 2011 Jan 1. MAbs. 2011. PMID: 21099371 Free PMC article.
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS. Waters JD, et al. Among authors: furfine e. J Neurooncol. 2012 Oct;110(1):37-48. doi: 10.1007/s11060-012-0948-7. Epub 2012 Aug 9. J Neurooncol. 2012. PMID: 22875706 Free PMC article.
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Ramamurthy V, Krystek SR Jr, Bush A, Wei A, Emanuel SL, Das Gupta R, Janjua A, Cheng L, Murdock M, Abramczyk B, Cohen D, Lin Z, Morin P, Davis JH, Dabritz M, McLaughlin DC, Russo KA, Chao G, Wright MC, Jenny VA, Engle LJ, Furfine E, Sheriff S. Ramamurthy V, et al. Among authors: furfine e. Structure. 2012 Feb 8;20(2):259-69. doi: 10.1016/j.str.2011.11.016. Structure. 2012. PMID: 22325775 Free article.
A Phase 2 Exploratory Study of a Novel Interleukin-1 Receptor Inhibitor (EBI-005) in the Treatment of Moderate-to-Severe Allergic Conjunctivitis.
Goldstein MH, Tubridy KL, Agahigian J, Furfine E, Magill M, Kovalchin J, Golden K, Zarbis-Papastoitsis G, Soong F, Salapatek AM, Sternberg G, Celniker A. Goldstein MH, et al. Among authors: furfine e. Eye Contact Lens. 2015 May;41(3):145-55. doi: 10.1097/ICL.0000000000000152. Eye Contact Lens. 2015. PMID: 25915834 Clinical Trial.
Design of a superior cytokine antagonist for topical ophthalmic use.
Hou J, Townson SA, Kovalchin JT, Masci A, Kiner O, Shu Y, King BM, Schirmer E, Golden K, Thomas C, Garcia KC, Zarbis-Papastoitsis G, Furfine ES, Barnes TM. Hou J, et al. Among authors: furfine es. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3913-8. doi: 10.1073/pnas.1217996110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431173 Free PMC article.
58 results