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SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.
Ritchie JP, Ramani VC, Ren Y, Naggi A, Torri G, Casu B, Penco S, Pisano C, Carminati P, Tortoreto M, Zunino F, Vlodavsky I, Sanderson RD, Yang Y. Ritchie JP, et al. Among authors: naggi a. Clin Cancer Res. 2011 Mar 15;17(6):1382-93. doi: 10.1158/1078-0432.CCR-10-2476. Epub 2011 Jan 21. Clin Cancer Res. 2011. PMID: 21257720 Free PMC article.
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD. Yang Y, et al. Among authors: naggi a. Blood. 2007 Sep 15;110(6):2041-8. doi: 10.1182/blood-2007-04-082495. Epub 2007 May 29. Blood. 2007. PMID: 17536013 Free PMC article.
Heparanase, heparin and the coagulation system in cancer progression.
Vlodavsky I, Ilan N, Nadir Y, Brenner B, Katz BZ, Naggi A, Torri G, Casu B, Sasisekharan R. Vlodavsky I, et al. Among authors: naggi a. Thromb Res. 2007;120 Suppl 2:S112-20. doi: 10.1016/S0049-3848(07)70139-1. Thromb Res. 2007. PMID: 18023704 Review.
Non-Anticoagulant Heparins as Heparanase Inhibitors.
Cassinelli G, Torri G, Naggi A. Cassinelli G, et al. Among authors: naggi a. Adv Exp Med Biol. 2020;1221:493-522. doi: 10.1007/978-3-030-34521-1_20. Adv Exp Med Biol. 2020. PMID: 32274724 Free PMC article. Review.
118 results