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SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.
Ritchie JP, Ramani VC, Ren Y, Naggi A, Torri G, Casu B, Penco S, Pisano C, Carminati P, Tortoreto M, Zunino F, Vlodavsky I, Sanderson RD, Yang Y. Ritchie JP, et al. Among authors: sanderson rd. Clin Cancer Res. 2011 Mar 15;17(6):1382-93. doi: 10.1158/1078-0432.CCR-10-2476. Epub 2011 Jan 21. Clin Cancer Res. 2011. PMID: 21257720 Free PMC article.
Soluble syndecan-1 promotes growth of myeloma tumors in vivo.
Yang Y, Yaccoby S, Liu W, Langford JK, Pumphrey CY, Theus A, Epstein J, Sanderson RD. Yang Y, et al. Among authors: sanderson rd. Blood. 2002 Jul 15;100(2):610-7. doi: 10.1182/blood.v100.2.610. Blood. 2002. PMID: 12091355 Free article.
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Yang Y, Macleod V, Bendre M, Huang Y, Theus AM, Miao HQ, Kussie P, Yaccoby S, Epstein J, Suva LJ, Kelly T, Sanderson RD. Yang Y, et al. Among authors: sanderson rd. Blood. 2005 Feb 1;105(3):1303-9. doi: 10.1182/blood-2004-06-2141. Epub 2004 Oct 7. Blood. 2005. PMID: 15471949 Free article.
135 results