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SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.
Ritchie JP, Ramani VC, Ren Y, Naggi A, Torri G, Casu B, Penco S, Pisano C, Carminati P, Tortoreto M, Zunino F, Vlodavsky I, Sanderson RD, Yang Y. Ritchie JP, et al. Among authors: vlodavsky i. Clin Cancer Res. 2011 Mar 15;17(6):1382-93. doi: 10.1158/1078-0432.CCR-10-2476. Epub 2011 Jan 21. Clin Cancer Res. 2011. PMID: 21257720 Free PMC article.
Involvement of heparanase in tumor progression and normal differentiation.
Vlodavsky I, Zcharia E, Goldshmidt O, Eshel R, Katz BZ, Minucci S, Kovalchuk O, Penco S, Pisano C, Naggi A, Casu B. Vlodavsky I, et al. Pathophysiol Haemost Thromb. 2003;33 Suppl 1:59-61. doi: 10.1159/000073296. Pathophysiol Haemost Thromb. 2003. PMID: 12955007 Free article. No abstract available.
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.
Zcharia E, Zilka R, Yaar A, Yacoby-Zeevi O, Zetser A, Metzger S, Sarid R, Naggi A, Casu B, Ilan N, Vlodavsky I, Abramovitch R. Zcharia E, et al. Among authors: vlodavsky i. FASEB J. 2005 Feb;19(2):211-21. doi: 10.1096/fj.04-1970com. FASEB J. 2005. PMID: 15677344
-Zcharia, E., Zilka, R., Yaar, A., Yacoby-Zeevi, O., Zetser, A., Metzger, S., Sarid, R., Naggi, A., Casu, B., Ilan, N., Vlodavsky, I., Abramovitch, R. Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models....
-Zcharia, E., Zilka, R., Yaar, A., Yacoby-Zeevi, O., Zetser, A., Metzger, S., Sarid, R., Naggi, A., Casu, B., Ilan, N., Vlodavsky, …
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD. Yang Y, et al. Among authors: vlodavsky i. Blood. 2007 Sep 15;110(6):2041-8. doi: 10.1182/blood-2007-04-082495. Epub 2007 May 29. Blood. 2007. PMID: 17536013 Free PMC article.
521 results