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Axonopathy is a compounding factor in the pathogenesis of Krabbe disease.
Castelvetri LC, Givogri MI, Zhu H, Smith B, Lopez-Rosas A, Qiu X, van Breemen R, Bongarzone ER. Castelvetri LC, et al. Among authors: lopez rosas a. Acta Neuropathol. 2011 Jul;122(1):35-48. doi: 10.1007/s00401-011-0814-2. Epub 2011 Mar 4. Acta Neuropathol. 2011. PMID: 21373782 Free PMC article.
The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors.
Cantuti Castelvetri L, Givogri MI, Hebert A, Smith B, Song Y, Kaminska A, Lopez-Rosas A, Morfini G, Pigino G, Sands M, Brady ST, Bongarzone ER. Cantuti Castelvetri L, et al. Among authors: lopez rosas a. J Neurosci. 2013 Jun 12;33(24):10048-56. doi: 10.1523/JNEUROSCI.0217-13.2013. J Neurosci. 2013. PMID: 23761900 Free PMC article.
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.
Smith BR, Santos MB, Marshall MS, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, van Breemen R, Claycomb KI, Gallea JI, Celej MS, Crocker SJ, Givogri MI, Bongarzone ER. Smith BR, et al. Among authors: lopez rosas a. J Pathol. 2014 Apr;232(5):509-21. doi: 10.1002/path.4328. Epub 2014 Feb 20. J Pathol. 2014. PMID: 24415155 Free PMC article.
26 results