Fairlamb AH - Search Results

1

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Spinks D, Ong HB, Mpamhanga CP, Shanks EJ, Robinson DA, Collie IT, Read KD, Frearson JA, Wyatt PG, Brenk R, Fairlamb AH, Gilbert IH. Spinks D, et al. Among authors: fairlamb ah. ChemMedChem. 2011 Feb 7;6(2):302-8. doi: 10.1002/cmdc.201000450. Epub 2010 Dec 29. ChemMedChem. 2011. PMID: 21275054 Free PMC article.

2

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: fairlamb ah. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

3

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase.

Hamilton CJ, Saravanamuthu A, Fairlamb AH, Eggleston IM. Hamilton CJ, et al. Among authors: fairlamb ah. Bioorg Med Chem. 2003 Aug 15;11(17):3683-93. doi: 10.1016/s0968-0896(03)00344-4. Bioorg Med Chem. 2003. PMID: 12901914

4

Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design.

Saravanamuthu A, Vickers TJ, Bond CS, Peterson MR, Hunter WN, Fairlamb AH. Saravanamuthu A, et al. Among authors: fairlamb ah. J Biol Chem. 2004 Jul 9;279(28):29493-500. doi: 10.1074/jbc.M403187200. Epub 2004 Apr 21. J Biol Chem. 2004. PMID: 15102853 Free PMC article.

5

Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products.

Hamilton CJ, Saravanamuthu A, Poupat C, Fairlamb AH, Eggleston IM. Hamilton CJ, et al. Among authors: fairlamb ah. Bioorg Med Chem. 2006 Apr 1;14(7):2266-78. doi: 10.1016/j.bmc.2005.11.004. Epub 2005 Nov 21. Bioorg Med Chem. 2006. PMID: 16303308

6

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.

Dawson A, Gibellini F, Sienkiewicz N, Tulloch LB, Fyfe PK, McLuskey K, Fairlamb AH, Hunter WN. Dawson A, et al. Among authors: fairlamb ah. Mol Microbiol. 2006 Sep;61(6):1457-68. doi: 10.1111/j.1365-2958.2006.05332.x. Mol Microbiol. 2006. PMID: 16968221 Free PMC article.

7

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.

Martyn DC, Jones DC, Fairlamb AH, Clardy J. Martyn DC, et al. Among authors: fairlamb ah. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3. doi: 10.1016/j.bmcl.2006.12.016. Epub 2006 Dec 9. Bioorg Med Chem Lett. 2007. PMID: 17197182 Free PMC article.

8

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Among authors: fairlamb ah. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

9

Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.

Sienkiewicz N, Jarosławski S, Wyllie S, Fairlamb AH. Sienkiewicz N, et al. Among authors: fairlamb ah. Mol Microbiol. 2008 Jul;69(2):520-33. doi: 10.1111/j.1365-2958.2008.06305.x. Mol Microbiol. 2008. PMID: 18557814 Free PMC article.

10

Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.

Perez-Pineiro R, Burgos A, Jones DC, Andrew LC, Rodriguez H, Suarez M, Fairlamb AH, Wishart DS. Perez-Pineiro R, et al. Among authors: fairlamb ah. J Med Chem. 2009 Mar 26;52(6):1670-80. doi: 10.1021/jm801306g. J Med Chem. 2009. PMID: 19296695 Free PMC article.

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