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Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.
Ruwanpura SM, McLeod L, Miller A, Jones J, Bozinovski S, Vlahos R, Ernst M, Armes J, Bardin PG, Anderson GP, Jenkins BJ. Ruwanpura SM, et al. Am J Respir Cell Mol Biol. 2011 Oct;45(4):720-30. doi: 10.1165/rcmb.2010-0462OC. Epub 2011 Feb 4. Am J Respir Cell Mol Biol. 2011. PMID: 21297079
ADAM17 Deficiency Protects against Pulmonary Emphysema.
Saad MI, McLeod L, Hodges C, Vlahos R, Rose-John S, Ruwanpura S, Jenkins BJ. Saad MI, et al. Am J Respir Cell Mol Biol. 2021 Feb;64(2):183-195. doi: 10.1165/rcmb.2020-0214OC. Am J Respir Cell Mol Biol. 2021. PMID: 33181031
Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ. Ruwanpura SM, et al. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505. doi: 10.1164/rccm.201512-2368OC. Am J Respir Crit Care Med. 2016. PMID: 27373892
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, West AC, West AJ, Weng T, Alanazi M, MacDonald M, King PT, Bardin PG, Gabay C, Klinman DM, Bozinovski S, Vlahos R, Anderson GP, Rose-John S, Saad MI, Jenkins BJ. Ruwanpura SM, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2201494119. doi: 10.1073/pnas.2201494119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037355 Free PMC article.
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S, Jenkins BJ. Brooks GD, et al. Cancer Res. 2016 Feb 15;76(4):866-76. doi: 10.1158/0008-5472.CAN-15-2388. Epub 2016 Jan 7. Cancer Res. 2016. PMID: 26744530
Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.
King PT, Sharma R, O'Sullivan KM, Callaghan J, Dousha L, Thomas B, Ruwanpura S, Lim S, Farmer MW, Jennings BR, Finsterbusch M, Brooks G, Selemidis S, Anderson GP, Holdsworth SR, Bardin PG. King PT, et al. Sci Rep. 2017 Sep 21;7(1):12128. doi: 10.1038/s41598-017-12474-5. Sci Rep. 2017. PMID: 28935869 Free PMC article.
33 results