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The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.
Chan P, Möller A, Liu MC, Sceneay JE, Wong CS, Waddell N, Huang KT, Dobrovic A, Millar EK, O'Toole SA, McNeil CM, Sutherland RL, Bowtell DD, Fox SB. Chan P, et al. Among authors: wong cs. Breast Cancer Res. 2011 Feb 9;13(1):R19. doi: 10.1186/bcr2828. Breast Cancer Res. 2011. PMID: 21306611 Free PMC article.
Inhibition of Siah ubiquitin ligase function.
Möller A, House CM, Wong CS, Scanlon DB, Liu MC, Ronai Z, Bowtell DD. Möller A, et al. Among authors: wong cs. Oncogene. 2009 Jan 15;28(2):289-96. doi: 10.1038/onc.2008.382. Epub 2008 Oct 13. Oncogene. 2009. PMID: 18850011 Free PMC article.
Siah: a promising anticancer target.
Wong CS, Möller A. Wong CS, et al. Cancer Res. 2013 Apr 15;73(8):2400-6. doi: 10.1158/0008-5472.CAN-12-4348. Epub 2013 Mar 1. Cancer Res. 2013. PMID: 23455005 Review.
1,145 results