Spear KL - Search Results

1

Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: spear kl. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1434-7. doi: 10.1016/j.bmcl.2011.01.019. Epub 2011 Jan 12. Bioorg Med Chem Lett. 2011. PMID: 21310612

2

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.

Shao L, Wang F, Malcolm SC, Ma J, Hewitt MC, Campbell UC, Bush LR, Spicer NA, Engel SR, Saraswat LD, Hardy LW, Koch P, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: spear kl. Bioorg Med Chem. 2011 Jan 1;19(1):663-76. doi: 10.1016/j.bmc.2010.10.034. Epub 2010 Oct 21. Bioorg Med Chem. 2011. PMID: 21093273

3

Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.

Shao L, Ma J, Wang F, Malcolm SC, Hewitt MC, Campbell UC, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: spear kl. Bioorg Med Chem Lett. 2011 Jan 1;21(1):520-3. doi: 10.1016/j.bmcl.2010.10.086. Epub 2010 Oct 28. Bioorg Med Chem Lett. 2011. PMID: 21095126

4

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: spear kl. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. doi: 10.1016/j.bmcl.2011.01.016. Epub 2011 Jan 12. Bioorg Med Chem Lett. 2011. PMID: 21310609

5

Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.

Shao L, Hewitt MC, Malcolm SC, Wang F, Ma J, Campbell UC, Spicer NA, Engel SR, Hardy LW, Jiang ZD, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: spear kl. J Med Chem. 2011 Aug 11;54(15):5283-95. doi: 10.1021/jm101312a. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739935

6

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH. Hopkins SC, et al. Among authors: spear kl. J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30. J Med Chem. 2013. PMID: 23631755

7

Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5.

Burdi DF, Hunt R, Fan L, Hu T, Wang J, Guo Z, Huang Z, Wu C, Hardy L, Detheux M, Orsini MA, Quinton MS, Lew R, Spear K. Burdi DF, et al. J Med Chem. 2010 Oct 14;53(19):7107-18. doi: 10.1021/jm100736h. J Med Chem. 2010. PMID: 20809633

8

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action.

Dedic N, Jones PG, Hopkins SC, Lew R, Shao L, Campbell JE, Spear KL, Large TH, Campbell UC, Hanania T, Leahy E, Koblan KS. Dedic N, et al. Among authors: spear kl. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. doi: 10.1124/jpet.119.260281. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371483

9

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. Among authors: spear kl. J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21. J Pharmacol Exp Ther. 2013. PMID: 23520265 Free article.

10

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.

Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH. Hopkins SC, et al. Among authors: spear kl. Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1. Pharmacol Res Perspect. 2013. PMID: 25505561 Free PMC article.

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