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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D'Alessio DA, Haupt A. Coskun T, et al. Mol Metab. 2018 Dec;18:3-14. doi: 10.1016/j.molmet.2018.09.009. Epub 2018 Oct 3. Mol Metab. 2018. PMID: 30473097 Free PMC article. Clinical Trial.
Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice.
Borg ML, Massart J, Schönke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR. Borg ML, et al. Among authors: alsina fernandez j. Diabetes. 2019 Jul;68(7):1403-1414. doi: 10.2337/db18-1237. Epub 2019 Apr 22. Diabetes. 2019. PMID: 31010957
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior.
Samms RJ, Cosgrove R, Snider BM, Furber EC, Droz BA, Briere DA, Dunbar J, Dogra M, Alsina-Fernandez J, Borner T, De Jonghe BC, Hayes MR, Coskun T, Sloop KW, Emmerson PJ, Ai M. Samms RJ, et al. Among authors: alsina fernandez j. Diabetes. 2022 Jul 1;71(7):1410-1423. doi: 10.2337/db21-0848. Diabetes. 2022. PMID: 35499381 Free PMC article.
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.
Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O'Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M. Li Y, et al. Cell. 2018 Nov 29;175(6):1561-1574.e12. doi: 10.1016/j.cell.2018.10.016. Epub 2018 Nov 15. Cell. 2018. PMID: 30449620 Free article.
Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice.
Snider B, Geiser A, Yu XP, Beebe EC, Willency JA, Qing K, Guo L, Lu J, Wang X, Yang Q, Efanov A, Adams AC, Coskun T, Emmerson PJ, Alsina-Fernandez J, Ai M. Snider B, et al. Among authors: alsina fernandez j. J Endocr Soc. 2019 May 16;3(7):1423-1444. doi: 10.1210/js.2019-00004. eCollection 2019 Jul 1. J Endocr Soc. 2019. PMID: 31286109 Free PMC article.
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