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Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.
Meli M, Tolomeo M, Grifantini M, Mai A, Cappellacci L, Petrelli R, Rotili D, Ferro A, Saiko P, Szekeres T, Dusonchet L. Meli M, et al. Among authors: tolomeo m. Int J Oncol. 2011 May;38(5):1427-36. doi: 10.3892/ijo.2011.943. Epub 2011 Feb 11. Int J Oncol. 2011. PMID: 21318222
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.
Petrelli R, Meli M, Vita P, Torquati I, Ferro A, Vodnala M, D'Alessandro N, Tolomeo M, Del Bello F, Kusumanchi P, Franchetti P, Grifantini M, Jayaram HN, Hofer A, Cappellacci L. Petrelli R, et al. Among authors: tolomeo m. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5304-9. doi: 10.1016/j.bmcl.2014.09.046. Epub 2014 Sep 28. Bioorg Med Chem Lett. 2014. PMID: 25304896
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells.
Tolomeo M, Grimaudo S, Di Cristina A, Roberti M, Pizzirani D, Meli M, Dusonchet L, Gebbia N, Abbadessa V, Crosta L, Barucchello R, Grisolia G, Invidiata F, Simoni D. Tolomeo M, et al. Int J Biochem Cell Biol. 2005 Aug;37(8):1709-26. doi: 10.1016/j.biocel.2005.03.004. Epub 2005 Apr 26. Int J Biochem Cell Biol. 2005. PMID: 15878840
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells.
Rondanin R, Simoni D, Maccesi M, Romagnoli R, Grimaudo S, Pipitone RM, Meli M, Cascio A, Tolomeo M. Rondanin R, et al. Among authors: tolomeo m. ChemMedChem. 2017 Aug 8;12(15):1183-1190. doi: 10.1002/cmdc.201700234. Epub 2017 Jul 19. ChemMedChem. 2017. PMID: 28657677
STAT5 and STAT5 Inhibitors in Hematological Malignancies.
Tolomeo M, Meli M, Grimaudo S. Tolomeo M, et al. Anticancer Agents Med Chem. 2019;19(17):2036-2046. doi: 10.2174/1871520619666190906160848. Anticancer Agents Med Chem. 2019. PMID: 31490767 Review.
115 results