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In vivo demonstration that alpha-synuclein oligomers are toxic.
Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. Winner B, et al. Among authors: desplats pa. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. doi: 10.1073/pnas.1100976108. Epub 2011 Feb 15. Proc Natl Acad Sci U S A. 2011. PMID: 21325059 Free PMC article.
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.
Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. Thomas EA, et al. Among authors: desplats pa. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. doi: 10.1073/pnas.0804249105. Epub 2008 Sep 30. Proc Natl Acad Sci U S A. 2008. PMID: 18829438 Free PMC article.
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.
Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Crews L, et al. PLoS One. 2010 Feb 19;5(2):e9313. doi: 10.1371/journal.pone.0009313. PLoS One. 2010. Retraction in: PLoS One. 2024 Nov 13;19(11):e0313935. doi: 10.1371/journal.pone.0313935. PMID: 20174468 Free PMC article. Retracted.
Cell-to-cell transmission of non-prion protein aggregates.
Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Lee SJ, et al. Nat Rev Neurol. 2010 Dec;6(12):702-6. doi: 10.1038/nrneurol.2010.145. Epub 2010 Oct 12. Nat Rev Neurol. 2010. PMID: 21045796 Free PMC article. Review.
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.
Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. Price DL, et al. PLoS One. 2010 Nov 16;5(11):e14020. doi: 10.1371/journal.pone.0014020. PLoS One. 2010. Retraction in: PLoS One. 2024 Nov 14;19(11):e0314138. doi: 10.1371/journal.pone.0314138. PMID: 21103359 Free PMC article. Retracted.
55 results