Leal N - Search Results

1

Pathophysiological idiosyncrasies and pharmacokinetic realities may interfere with tacrolimus dose titration in liver transplantation.

Oteo I, Lukas JC, Leal N, Suarez E, Valdivieso A, Gastaca M, de Urbina JO, Calvo R. Oteo I, et al. Among authors: leal n. Eur J Clin Pharmacol. 2011 Jul;67(7):671-9. doi: 10.1007/s00228-011-0998-3. Epub 2011 Feb 17. Eur J Clin Pharmacol. 2011. PMID: 21327908 Free article. Clinical Trial.

2

Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction.

Oteo I, Lukas JC, Leal N, Suarez E, Valdivieso A, Gastaca M, Ortiz de Urbina J, Calvo R. Oteo I, et al. Among authors: leal n. Eur J Clin Pharmacol. 2013 Jan;69(1):65-74. doi: 10.1007/s00228-012-1300-z. Epub 2012 Jun 3. Eur J Clin Pharmacol. 2013. PMID: 22660442

3

Tacrolimus dose individualization in "de novo" patients after 10 years of experience in liver transplantation: pharmacokinetic considerations and patient pathophysiology.

Valdivieso N, Oteo I, Valdivieso A, Lukas JC, Leal N, Gastaca M, de Urbina JO, Calvo R, Suarez E. Valdivieso N, et al. Among authors: leal n. Int J Clin Pharmacol Ther. 2013 Jul;51(7):606-14. doi: 10.5414/CP201800. Int J Clin Pharmacol Ther. 2013. PMID: 23735178

4

Altered dose-to-effect of propofol due to pharmacokinetics in rats with experimental diabetes mellitus.

Leal N, Calvo R, Agrad FZ, Lukas JC, de la Fuente L, Suarez E. Leal N, et al. J Pharm Pharmacol. 2005 Mar;57(3):317-25. doi: 10.1211/0022357055498. J Pharm Pharmacol. 2005. PMID: 15807987

5

The role of unbound drug in pharmacokinetics/pharmacodynamics and in therapy.

Calvo R, Lukas JC, Rodriguez M, Leal N, Suarez E. Calvo R, et al. Among authors: leal n. Curr Pharm Des. 2006;12(8):977-87. doi: 10.2174/138161206776055967. Curr Pharm Des. 2006. PMID: 16533165

6

Influence of formulation on propofol pharmacokinetics and pharmacodynamics in anesthetized patients.

Calvo R, Telletxea S, Leal N, Aguilera L, Suarez E, De La Fuente L, Martin-Suarez A, Lukas JC. Calvo R, et al. Among authors: leal n. Acta Anaesthesiol Scand. 2004 Sep;48(8):1038-48. doi: 10.1111/j.0001-5172.2004.00467.x. Acta Anaesthesiol Scand. 2004. PMID: 15315624

7

Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding.

Rodriguez M, Ortega I, Soengas I, Leal N, Suarez E, Calvo R, Lukas JC. Rodriguez M, et al. Among authors: leal n. J Pharm Sci. 2004 Nov;93(11):2836-50. doi: 10.1002/jps.20171. J Pharm Sci. 2004. PMID: 15452846

8

Application of a dual mechanistic approach to support bilastine dose selection for older adults.

Kim C, Lo Re V, Rodriguez M, Lukas JC, Leal N, Campo C, García-Bea A, Suarez E, Schmidt S, Vozmediano V. Kim C, et al. Among authors: leal n. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1006-1017. doi: 10.1002/psp4.12671. Epub 2021 Aug 1. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34157202 Free PMC article.

9

Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design.

Vozmediano V, Sologuren A, Lukas JC, Leal N, Rodriguez M. Vozmediano V, et al. Among authors: leal n. Pharm Res. 2017 Dec;34(12):2720-2734. doi: 10.1007/s11095-017-2248-6. Epub 2017 Oct 2. Pharm Res. 2017. PMID: 28971281 Clinical Trial.

10

Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine.

Jauregizar N, de la Fuente L, Lucero ML, Sologuren A, Leal N, Rodríguez M. Jauregizar N, et al. Among authors: leal n. Clin Pharmacokinet. 2009;48(8):543-54. doi: 10.2165/11317180-000000000-00000. Clin Pharmacokinet. 2009. PMID: 19705924 Clinical Trial.

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