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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Zhao R, et al. Among authors: shaikenov t. J Clin Invest. 2011 Mar;121(3):851-65. doi: 10.1172/JCI44111. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317535 Free PMC article.
CSN6 drives carcinogenesis by positively regulating Myc stability.
Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. Chen J, et al. Among authors: shaikenov t. Nat Commun. 2014 Nov 14;5:5384. doi: 10.1038/ncomms6384. Nat Commun. 2014. PMID: 25395170 Free PMC article.
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.
Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Abu-Elheiga L, et al. Among authors: shaikenov t. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12011-6. doi: 10.1073/pnas.0505714102. Epub 2005 Aug 15. Proc Natl Acad Sci U S A. 2005. PMID: 16103361 Free PMC article.