Kozielski F - Search Results

1

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2011 Mar 24;54(6):1576-86. doi: 10.1021/jm100991m. Epub 2011 Feb 23. J Med Chem. 2011. PMID: 21344920

2

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F. Debonis S, et al. Among authors: kozielski f. J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266314

3

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

Putey A, Popowycz F, Do QT, Bernard P, Talapatra SK, Kozielski F, Galmarini CM, Joseph B. Putey A, et al. Among authors: kozielski f. J Med Chem. 2009 Oct 8;52(19):5916-25. doi: 10.1021/jm900476c. J Med Chem. 2009. PMID: 19743863

4

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.

Kaan HY, Ulaganathan V, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Biochem J. 2009 Dec 14;425(1):55-60. doi: 10.1042/BJ20091207. Biochem J. 2009. PMID: 19793049

5

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n. J Med Chem. 2010. PMID: 20597485

6

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F. Wang F, et al. Among authors: kozielski f. J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13. J Med Chem. 2012. PMID: 22248262 Free PMC article.

7

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F. Good JA, et al. Among authors: kozielski f. J Med Chem. 2013 Mar 14;56(5):1878-93. doi: 10.1021/jm3014597. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23394180 Free PMC article.

8

"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.

Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS. Kaan HY, et al. Among authors: kozielski f. J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658017 Free PMC article.

9

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

Popowycz F, Schneider C, Debonis S, Skoufias DA, Kozielski F, Galmarini CM, Joseph B. Popowycz F, et al. Among authors: kozielski f. Bioorg Med Chem. 2009 May 1;17(9):3471-8. doi: 10.1016/j.bmc.2009.03.007. Epub 2009 Mar 10. Bioorg Med Chem. 2009. PMID: 19349183

10

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

Prokopcová H, Dallinger D, Uray G, Kaan HY, Ulaganathan V, Kozielski F, Laggner C, Kappe CO. Prokopcová H, et al. Among authors: kozielski f. ChemMedChem. 2010 Oct 4;5(10):1760-9. doi: 10.1002/cmdc.201000252. ChemMedChem. 2010. PMID: 20737530

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