Caron N - Search Results

1

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R. Munsie L, et al. Among authors: caron n. Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25. Hum Mol Genet. 2011. PMID: 21355047 Free PMC article.

2

Lifeact cannot visualize some forms of stress-induced twisted F-actin.

Munsie LN, Caron N, Desmond CR, Truant R. Munsie LN, et al. Among authors: caron n. Nat Methods. 2009 May;6(5):317. doi: 10.1038/nmeth0509-317. Nat Methods. 2009. PMID: 19404250 No abstract available.

3

Kinase inhibitors modulate huntingtin cell localization and toxicity.

Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S, Truant R. Atwal RS, et al. Among authors: caron n. Nat Chem Biol. 2011 May 29;7(7):453-60. doi: 10.1038/nchembio.582. Nat Chem Biol. 2011. PMID: 21623356

4

Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.

Caron NS, Munsie LN, Keillor JW, Truant R. Caron NS, et al. PLoS One. 2012;7(8):e44159. doi: 10.1371/journal.pone.0044159. Epub 2012 Aug 31. PLoS One. 2012. PMID: 22952912 Free PMC article.

5

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Caron NS, Desmond CR, Xia J, Truant R. Caron NS, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29. Proc Natl Acad Sci U S A. 2013. PMID: 23898200 Free PMC article.

6

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.

Caron NS, Hung CL, Atwal RS, Truant R. Caron NS, et al. Hum Mol Genet. 2014 May 1;23(9):2324-38. doi: 10.1093/hmg/ddt625. Epub 2013 Dec 11. Hum Mol Genet. 2014. PMID: 24334607

7

Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.

Caron NS, Banos R, Yanick C, Aly AE, Byrne LM, Smith ED, Xie Y, Smith SEP, Potluri N, Findlay Black H, Casal L, Ko S, Cheung D, Kim H, Seong IS, Wild EJ, Song JJ, Hayden MR, Southwell AL. Caron NS, et al. J Neurosci. 2021 Jan 27;41(4):780-796. doi: 10.1523/JNEUROSCI.1865-20.2020. Epub 2020 Dec 11. J Neurosci. 2021. PMID: 33310753 Free PMC article.

8

Functional characterization of variants of unknown significance in a spinocerebellar ataxia patient using an unsupervised machine learning pipeline.

Nath S, Caron NS, May L, Gluscencova OB, Kolesar J, Brady L, Kaufman BA, Boulianne GL, Rodriguez AR, Tarnopolsky MA, Truant R. Nath S, et al. Hum Genome Var. 2022 Apr 14;9(1):10. doi: 10.1038/s41439-022-00188-8. Hum Genome Var. 2022. PMID: 35422034 Free PMC article.

9

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.

Caron NS, Byrne LM, Lemarié FL, Bone JN, Aly AE, Ko S, Anderson C, Casal LL, Hill AM, Hawellek DJ, McColgan P, Wild EJ, Leavitt BR, Hayden MR. Caron NS, et al. Transl Neurodegener. 2024 Oct 8;13(1):50. doi: 10.1186/s40035-024-00443-8. Transl Neurodegener. 2024. PMID: 39380076 Free PMC article.

10

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR. Ehrnhoefer DE, et al. Among authors: caron ns. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25. Cell Chem Biol. 2019. PMID: 31353319 Free PMC article.

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