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Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.
J Biol Chem. 2011 Apr 29;286(17):15240-51. doi: 10.1074/jbc.M110.213587. Epub 2011 Feb 25.
J Biol Chem. 2011.
PMID: 21357415
Free PMC article.
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H.
Page RM, et al. Among authors: gutsmiedl a.
J Biol Chem. 2010 Jun 4;285(23):17798-810. doi: 10.1074/jbc.M110.103283. Epub 2010 Mar 26.
J Biol Chem. 2010.
PMID: 20348104
Free PMC article.
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