Stiff T - Search Results

1

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.

Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA. Bicknell LS, et al. Among authors: stiff t. Nat Genet. 2011 Feb 27;43(4):350-5. doi: 10.1038/ng.776. Nat Genet. 2011. PMID: 21358633

2

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.

Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Riballo E, et al. Among authors: stiff t. J Biol Chem. 2001 Aug 17;276(33):31124-32. doi: 10.1074/jbc.M103866200. Epub 2001 May 10. J Biol Chem. 2001. PMID: 11349135 Free article.

3

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA. Stiff T, et al. Cancer Res. 2004 Apr 1;64(7):2390-6. doi: 10.1158/0008-5472.can-03-3207. Cancer Res. 2004. PMID: 15059890

4

Nbs1 is required for ATR-dependent phosphorylation events.

Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA. Stiff T, et al. EMBO J. 2005 Jan 12;24(1):199-208. doi: 10.1038/sj.emboj.7600504. Epub 2004 Dec 16. EMBO J. 2005. PMID: 15616588 Free PMC article.

5

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA. Stiff T, et al. EMBO J. 2006 Dec 13;25(24):5775-82. doi: 10.1038/sj.emboj.7601446. Epub 2006 Nov 23. EMBO J. 2006. PMID: 17124492 Free PMC article.

6

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.

Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M. Griffith E, et al. Among authors: stiff t. Nat Genet. 2008 Feb;40(2):232-6. doi: 10.1038/ng.2007.80. Epub 2007 Dec 23. Nat Genet. 2008. PMID: 18157127 Free PMC article.

7

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.

Stiff T, Cerosaletti K, Concannon P, O'Driscoll M, Jeggo PA. Stiff T, et al. Hum Mol Genet. 2008 Oct 15;17(20):3247-53. doi: 10.1093/hmg/ddn220. Epub 2008 Jul 28. Hum Mol Genet. 2008. PMID: 18664457 Free PMC article.

8

XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation.

Riballo E, Woodbine L, Stiff T, Walker SA, Goodarzi AA, Jeggo PA. Riballo E, et al. Among authors: stiff t. Nucleic Acids Res. 2009 Feb;37(2):482-92. doi: 10.1093/nar/gkn957. Epub 2008 Dec 4. Nucleic Acids Res. 2009. PMID: 19056826 Free PMC article.

9

The limitations of the G1-S checkpoint.

Deckbar D, Stiff T, Koch B, Reis C, Löbrich M, Jeggo PA. Deckbar D, et al. Among authors: stiff t. Cancer Res. 2010 Jun 1;70(11):4412-21. doi: 10.1158/0008-5472.CAN-09-3198. Epub 2010 May 11. Cancer Res. 2010. PMID: 20460507

10

DNA double-strand break repair within heterochromatic regions.

Murray JM, Stiff T, Jeggo PA. Murray JM, et al. Among authors: stiff t. Biochem Soc Trans. 2012 Feb;40(1):173-8. doi: 10.1042/BST20110631. Biochem Soc Trans. 2012. PMID: 22260685 Review.

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