Darkes MC - Search Results

1

HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.

Labrecque J, Metz M, Lau G, Darkes MC, Wong RS, Bogucki D, Carpenter B, Chen G, Li T, Nan S, Schols D, Bridger GJ, Fricker SP, Skerlj RT. Labrecque J, et al. Among authors: darkes mc. Virology. 2011 May 10;413(2):231-43. doi: 10.1016/j.virol.2011.02.016. Epub 2011 Mar 9. Virology. 2011. PMID: 21388649 Free article.

2

The development of an europium-GTP assay to quantitate chemokine antagonist interactions for CXCR4 and CCR5.

Labrecque J, Anastassov V, Lau G, Darkes M, Mosi R, Fricker SP. Labrecque J, et al. Assay Drug Dev Technol. 2005 Dec;3(6):637-48. doi: 10.1089/adt.2005.3.637. Assay Drug Dev Technol. 2005. PMID: 16438659

3

Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.

Skerlj R, Bridger G, Zhou Y, Bourque E, Langille J, Di Fluri M, Bogucki D, Yang W, Li T, Wang L, Nan S, Baird I, Metz M, Darkes M, Labrecque J, Lau G, Fricker S, Huskens D, Schols D. Skerlj R, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2450-5. doi: 10.1016/j.bmcl.2011.02.058. Epub 2011 Feb 23. Bioorg Med Chem Lett. 2011. PMID: 21398122

4

Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

Metz M, Bourque E, Labrecque J, Danthi SJ, Langille J, Harwig C, Yang W, Darkes MC, Lau G, Santucci Z, Bridger GJ, Schols D, Fricker SP, Skerlj RT. Metz M, et al. Among authors: darkes mc. J Am Chem Soc. 2011 Oct 19;133(41):16477-85. doi: 10.1021/ja2043722. Epub 2011 Sep 23. J Am Chem Soc. 2011. PMID: 21942640

5

The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.

Mosi RM, Anastassova V, Cox J, Darkes MC, Idzan SR, Labrecque J, Lau G, Nelson KL, Patel K, Santucci Z, Wong RS, Skerlj RT, Bridger GJ, Huskens D, Schols D, Fricker SP. Mosi RM, et al. Among authors: darkes mc. Biochem Pharmacol. 2012 Feb 15;83(4):472-9. doi: 10.1016/j.bcp.2011.11.020. Epub 2011 Nov 28. Biochem Pharmacol. 2012. PMID: 22146583

6

Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.

Bodart V, Anastassov V, Darkes MC, Idzan SR, Labrecque J, Lau G, Mosi RM, Neff KS, Nelson KL, Ruzek MC, Patel K, Santucci Z, Scarborough R, Wong RS, Bridger GJ, Macfarland RT, Fricker SP. Bodart V, et al. Among authors: darkes mc. Biochem Pharmacol. 2009 Oct 15;78(8):993-1000. doi: 10.1016/j.bcp.2009.06.010. Epub 2009 Jun 18. Biochem Pharmacol. 2009. PMID: 19540208

7

Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.

Fricker SP, Anastassov V, Cox J, Darkes MC, Grujic O, Idzan SR, Labrecque J, Lau G, Mosi RM, Nelson KL, Qin L, Santucci Z, Wong RS. Fricker SP, et al. Among authors: darkes mc. Biochem Pharmacol. 2006 Aug 28;72(5):588-96. doi: 10.1016/j.bcp.2006.05.010. Epub 2006 Jul 3. Biochem Pharmacol. 2006. PMID: 16815309

8

Ruthenium(III) polyaminocarboxylate complexes: efficient and effective nitric oxide scavengers.

Cameron BR, Darkes MC, Yee H, Olsen M, Fricker SP, Skerlj RT, Bridger GJ, Davies NA, Wilson MT, Rose DJ, Zubieta J. Cameron BR, et al. Among authors: darkes mc. Inorg Chem. 2003 Mar 24;42(6):1868-76. doi: 10.1021/ic020219+. Inorg Chem. 2003. PMID: 12639119

9

Ruthenium(III) triazacyclononane dithiocarbamate, pyridinecarboxylate, or aminocarboxylate complexes as scavengers of nitric oxide.

Cameron BR, Darkes MC, Baird IR, Skerlj RT, Santucci ZL, Fricker SP. Cameron BR, et al. Among authors: darkes mc. Inorg Chem. 2003 Jun 30;42(13):4102-8. doi: 10.1021/ic020283r. Inorg Chem. 2003. PMID: 12817968

10

Mechanistic studies on AMD6221: a ruthenium-based nitric oxide scavenger.

Mosi R, Seguin B, Cameron B, Amankwa L, Darkes MC, Fricker SP. Mosi R, et al. Among authors: darkes mc. Biochem Biophys Res Commun. 2002 Mar 29;292(2):519-29. doi: 10.1006/bbrc.2002.6685. Biochem Biophys Res Commun. 2002. PMID: 11906192

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