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Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.
Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE. Hrycyna CA, et al. Among authors: kirk k. ACS Chem Biol. 2014 Mar 21;9(3):722-30. doi: 10.1021/cb4008953. Epub 2014 Jan 6. ACS Chem Biol. 2014. PMID: 24369685 Free PMC article.
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.
Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE. Summers RL, et al. Among authors: kirk k. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1759-67. doi: 10.1073/pnas.1322965111. Epub 2014 Apr 11. Proc Natl Acad Sci U S A. 2014. PMID: 24728833 Free PMC article.
1H-NMR metabolite profiles of different strains of Plasmodium falciparum.
Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K. Teng R, et al. Among authors: kirk k. Biosci Rep. 2014 Nov 21;34(6):e00150. doi: 10.1042/BSR20140134. Biosci Rep. 2014. PMID: 25405893 Free PMC article.
Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.
Martin RE, Butterworth AS, Gardiner DL, Kirk K, McCarthy JS, Skinner-Adams TS. Martin RE, et al. Among authors: kirk k. Antimicrob Agents Chemother. 2012 May;56(5):2283-9. doi: 10.1128/AAC.00166-12. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354298 Free PMC article.
Membrane transport proteins of the malaria parasite.
Martin RE, Ginsburg H, Kirk K. Martin RE, et al. Among authors: kirk k. Mol Microbiol. 2009 Nov;74(3):519-28. doi: 10.1111/j.1365-2958.2009.06863.x. Epub 2009 Oct 1. Mol Microbiol. 2009. PMID: 19796339 Free article.
937 results