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Page 1
The role of translational bioinformatics in drug discovery.
Buchan NS, Rajpal DK, Webster Y, Alatorre C, Gudivada RC, Zheng C, Sanseau P, Koehler J. Buchan NS, et al. Drug Discov Today. 2011 May;16(9-10):426-34. doi: 10.1016/j.drudis.2011.03.002. Epub 2011 Mar 21. Drug Discov Today. 2011. PMID: 21402166 Review.
Network analysis has diverse roles in drug discovery.
Hasan S, Bonde BK, Buchan NS, Hall MD. Hasan S, et al. Among authors: buchan ns. Drug Discov Today. 2012 Aug;17(15-16):869-74. doi: 10.1016/j.drudis.2012.05.006. Epub 2012 May 22. Drug Discov Today. 2012. PMID: 22627007 Review.
The integrated disease network.
Sun K, Buchan N, Larminie C, Pržulj N. Sun K, et al. Integr Biol (Camb). 2014 Nov;6(11):1069-79. doi: 10.1039/c4ib00122b. Integr Biol (Camb). 2014. PMID: 25133803
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, Zheng J, Johnson T, Koprulu M, Zengini E, Steinberg J, Wilkinson JM, Bhatnagar S, Hoffman JD, Buchan N, Süveges D; arcOGEN Consortium; Yerges-Armstrong L, Smith GD, Gaunt TR, Scott RA, McCarthy LC, Zeggini E. Tachmazidou I, et al. Nat Genet. 2019 Feb;51(2):230-236. doi: 10.1038/s41588-018-0327-1. Epub 2019 Jan 21. Nat Genet. 2019. PMID: 30664745 Free PMC article.
Pharmacological validation of targets regulating CD14 during macrophage differentiation.
Jimenez-Duran G, Luque-Martin R, Patel M, Koppe E, Bernard S, Sharp C, Buchan N, Rea C, de Winther MPJ, Turan N, Angell D, Wells CA, Cousins R, Mander PK, Masters SL. Jimenez-Duran G, et al. EBioMedicine. 2020 Nov;61:103039. doi: 10.1016/j.ebiom.2020.103039. Epub 2020 Oct 7. EBioMedicine. 2020. PMID: 33038762 Free PMC article.