Isaacs JS - Search Results

1

A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

Gopal U, Bohonowych JE, Lema-Tome C, Liu A, Garrett-Mayer E, Wang B, Isaacs JS. Gopal U, et al. Among authors: isaacs js. PLoS One. 2011 Mar 8;6(3):e17649. doi: 10.1371/journal.pone.0017649. PLoS One. 2011. PMID: 21408136 Free PMC article.

2

Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironment.

Bohonowych JE, Hance MW, Nolan KD, Defee M, Parsons CH, Isaacs JS. Bohonowych JE, et al. Among authors: isaacs js. Prostate. 2014 Apr;74(4):395-407. doi: 10.1002/pros.22761. Epub 2013 Dec 16. Prostate. 2014. PMID: 24338924 Free PMC article.

3

Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.

Hance MW, Dole K, Gopal U, Bohonowych JE, Jezierska-Drutel A, Neumann CA, Liu H, Garraway IP, Isaacs JS. Hance MW, et al. Among authors: isaacs js. J Biol Chem. 2012 Nov 2;287(45):37732-44. doi: 10.1074/jbc.M112.389015. Epub 2012 Sep 18. J Biol Chem. 2012. PMID: 22989880 Free PMC article.

4

Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.

Annamalai B, Liu X, Gopal U, Isaacs JS. Annamalai B, et al. Among authors: isaacs js. Mol Cancer Res. 2009 Jul;7(7):1021-32. doi: 10.1158/1541-7786.MCR-08-0582. Epub 2009 Jun 30. Mol Cancer Res. 2009. PMID: 19567782 Free PMC article.

5

Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.

Bohonowych JE, Gopal U, Isaacs JS. Bohonowych JE, et al. Among authors: isaacs js. J Oncol. 2010;2010:412985. doi: 10.1155/2010/412985. Epub 2010 Jun 24. J Oncol. 2010. PMID: 20628489 Free PMC article.

6

Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling.

Daoud A, Gopal U, Kaur J, Isaacs JS. Daoud A, et al. Among authors: isaacs js. Oncotarget. 2017 Nov 3;8(63):106807-106819. doi: 10.18632/oncotarget.22370. eCollection 2017 Dec 5. Oncotarget. 2017. PMID: 29290990 Free PMC article.

7

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.

Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS. Bohonowych JE, et al. Among authors: isaacs js. BMC Cancer. 2011 Dec 15;11:520. doi: 10.1186/1471-2407-11-520. BMC Cancer. 2011. PMID: 22172030 Free PMC article.

8

Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.

Nolan KD, Franco OE, Hance MW, Hayward SW, Isaacs JS. Nolan KD, et al. Among authors: isaacs js. J Biol Chem. 2015 Mar 27;290(13):8271-82. doi: 10.1074/jbc.M115.637496. Epub 2015 Feb 10. J Biol Chem. 2015. PMID: 25670862 Free PMC article.

9

Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.

Qin Z, DeFee M, Isaacs JS, Parsons C. Qin Z, et al. Among authors: isaacs js. Virology. 2010 Jul 20;403(1):92-102. doi: 10.1016/j.virol.2010.03.052. Epub 2010 May 6. Virology. 2010. PMID: 20451233 Free PMC article.

10

Hsp90 as a "Chaperone" of the Epigenome: Insights and Opportunities for Cancer Therapy.

Isaacs JS. Isaacs JS. Adv Cancer Res. 2016;129:107-40. doi: 10.1016/bs.acr.2015.09.003. Epub 2015 Nov 24. Adv Cancer Res. 2016. PMID: 26916003 Review.

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