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Page 1
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.
Tran TD, Pryde DC, Jones P, Adam FM, Benson N, Bish G, Calo F, Ciaramella G, Dixon R, Duckworth J, Fox DN, Hay DA, Hitchin J, Horscroft N, Howard M, Gardner I, Jones HM, Laxton C, Parkinson T, Parsons G, Proctor K, Smith MC, Smith N, Thomas A. Tran TD, et al. Among authors: pryde dc. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2389-93. doi: 10.1016/j.bmcl.2011.02.092. Epub 2011 Mar 16. Bioorg Med Chem Lett. 2011. PMID: 21419626
Discovery of a highly potent series of TLR7 agonists.
Jones P, Pryde DC, Tran TD, Adam FM, Bish G, Calo F, Ciaramella G, Dixon R, Duckworth J, Fox DN, Hay DA, Hitchin J, Horscroft N, Howard M, Laxton C, Parkinson T, Parsons G, Proctor K, Smith MC, Smith N, Thomas A. Jones P, et al. Among authors: pryde dc. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5939-43. doi: 10.1016/j.bmcl.2011.07.076. Epub 2011 Aug 4. Bioorg Med Chem Lett. 2011. PMID: 21885277
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.
Pryde DC, Tran TD, Jones P, Duckworth J, Howard M, Gardner I, Hyland R, Webster R, Wenham T, Bagal S, Omoto K, Schneider RP, Lin J. Pryde DC, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2856-60. doi: 10.1016/j.bmcl.2012.02.069. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22429467
Non-benzimidazole containing inhibitors of respiratory syncytial virus.
Pryde DC, Tran TD, Gardner I, Bright H, Stupple P, Galan S, Alsop L, Watson L, Middleton DS, Dayal S, Platts M, Murray EJ, Parkinson T, Webster R. Pryde DC, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23265891
The design and discovery of novel amide CCR5 antagonists.
Pryde DC, Corless M, Fenwick DR, Mason HJ, Stammen BC, Stephenson PT, Ellis D, Bachelor D, Gordon D, Barber CG, Wood A, Middleton DS, Blakemore DC, Parsons GC, Eastwood R, Platts MY, Statham K, Paradowski KA, Burt C, Klute W. Pryde DC, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1084-8. doi: 10.1016/j.bmcl.2009.01.012. Epub 2009 Jan 10. Bioorg Med Chem Lett. 2009. PMID: 19167884
Antiviral applications of Toll-like receptor agonists.
Horscroft NJ, Pryde DC, Bright H. Horscroft NJ, et al. Among authors: pryde dc. J Antimicrob Chemother. 2012 Apr;67(4):789-801. doi: 10.1093/jac/dkr588. Epub 2012 Jan 18. J Antimicrob Chemother. 2012. PMID: 22258929 Review.
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 1.
Tran TD, Wakenhut F, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Brimage RA, Halstead R, Glen R, Wilson CP, Adam F, Hay D, Chiva JY, Nichols C, Blakemore DC, Gardner I, Dayal S, Pike A, Webster R, Pryde DC. Tran TD, et al. Among authors: pryde dc. ChemMedChem. 2014 Jul;9(7):1378-86. doi: 10.1002/cmdc.201400045. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729513
55 results