Aptula AO - Search Results

1

Refinement of the Dermal Sensitisation Threshold (DST) approach using a larger dataset and incorporating mechanistic chemistry domains.

Safford RJ, Aptula AO, Gilmour N. Safford RJ, et al. Among authors: aptula ao. Regul Toxicol Pharmacol. 2011 Jul;60(2):218-24. doi: 10.1016/j.yrtph.2011.03.009. Epub 2011 Apr 3. Regul Toxicol Pharmacol. 2011. PMID: 21447365

2

Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization.

Aptula AO, Patlewicz G, Roberts DW, Schultz TW. Aptula AO, et al. Toxicol In Vitro. 2006 Mar;20(2):239-47. doi: 10.1016/j.tiv.2005.07.003. Epub 2005 Aug 19. Toxicol In Vitro. 2006. PMID: 16112535

3

Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships.

Aptula AO, Patlewicz G, Roberts DW. Aptula AO, et al. Chem Res Toxicol. 2005 Sep;18(9):1420-6. doi: 10.1021/tx050075m. Chem Res Toxicol. 2005. PMID: 16167834

4

Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: general principles and application to reactive toxicity.

Aptula AO, Roberts DW. Aptula AO, et al. Chem Res Toxicol. 2006 Aug;19(8):1097-105. doi: 10.1021/tx0601004. Chem Res Toxicol. 2006. PMID: 16918251

5

Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay.

Roberts DW, Aptula AO, Patlewicz G. Roberts DW, et al. Among authors: aptula ao. Chem Res Toxicol. 2007 Jan;20(1):44-60. doi: 10.1021/tx060121y. Chem Res Toxicol. 2007. PMID: 17226926 Review.

6

TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.

Patlewicz G, Dimitrov SD, Low LK, Kern PS, Dimitrova GD, Comber MI, Aptula AO, Phillips RD, Niemelä J, Madsen C, Wedebye EB, Roberts DW, Bailey PT, Mekenyan OG. Patlewicz G, et al. Among authors: aptula ao. Regul Toxicol Pharmacol. 2007 Jul;48(2):225-39. doi: 10.1016/j.yrtph.2007.03.003. Epub 2007 Mar 25. Regul Toxicol Pharmacol. 2007. PMID: 17467128

7

TIMES-SS--a mechanistic evaluation of an external validation study using reaction chemistry principles.

Roberts DW, Patlewicz G, Dimitrov SD, Low LK, Aptula AO, Kern PS, Dimitrova GD, Comber MI, Phillips RD, Niemelä J, Madsen C, Wedebye EB, Bailey PT, Mekenyan OG. Roberts DW, et al. Among authors: aptula ao. Chem Res Toxicol. 2007 Sep;20(9):1321-30. doi: 10.1021/tx700169w. Epub 2007 Aug 23. Chem Res Toxicol. 2007. PMID: 17713962

8

Assuring consumer safety without animal testing: a feasibility case study for skin sensitisation.

Maxwell G, Aleksic M, Aptula A, Carmichael P, Fentem J, Gilmour N, Mackay C, Pease C, Pendlington R, Reynolds F, Scott D, Warner G, Westmoreland C. Maxwell G, et al. Altern Lab Anim. 2008 Nov;36(5):557-68. doi: 10.1177/026119290803600511. Altern Lab Anim. 2008. PMID: 19025323

9

Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: skin sensitisation.

Goebel C, Aeby P, Ade N, Alépée N, Aptula A, Araki D, Dufour E, Gilmour N, Hibatallah J, Keller D, Kern P, Kirst A, Marrec-Fairley M, Maxwell G, Rowland J, Safford B, Schellauf F, Schepky A, Seaman C, Teichert T, Tessier N, Teissier S, Weltzien HU, Winkler P, Scheel J. Goebel C, et al. Regul Toxicol Pharmacol. 2012 Jun;63(1):40-52. doi: 10.1016/j.yrtph.2012.02.007. Epub 2012 Feb 21. Regul Toxicol Pharmacol. 2012. PMID: 22374415 Free article.

10

A practical guidance for Cramer class determination.

Roberts DW, Aptula A, Schultz TW, Shen J, Api AM, Bhatia S, Kromidas L. Roberts DW, et al. Regul Toxicol Pharmacol. 2015 Dec;73(3):971-84. doi: 10.1016/j.yrtph.2015.09.017. Epub 2015 Sep 14. Regul Toxicol Pharmacol. 2015. PMID: 26382611

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