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A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.
Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. Johnson RL, et al. Among authors: austin cp. J Biomol Screen. 2011 Jul;16(6):618-27. doi: 10.1177/1087057111402199. Epub 2011 Apr 11. J Biomol Screen. 2011. PMID: 21482722 Free PMC article.
Dose-response modeling of high-throughput screening data.
Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Parham F, et al. J Biomol Screen. 2009 Dec;14(10):1216-27. doi: 10.1177/1087057109349355. J Biomol Screen. 2009. PMID: 19828774 Free PMC article.
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.
Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Hwang JY, et al. Among authors: austin cp. J Biol Chem. 2011 Apr 8;286(14):11895-908. doi: 10.1074/jbc.M110.200436. Epub 2011 Feb 14. J Biol Chem. 2011. PMID: 21321127 Free PMC article.
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Zheng W, et al. Among authors: austin cp. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. doi: 10.1073/pnas.0705637104. Epub 2007 Aug 1. Proc Natl Acad Sci U S A. 2007. PMID: 17670938 Free PMC article.
271 results