Pyrah I - Search Results

1

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys.

Ominsky MS, Stouch B, Schroeder J, Pyrah I, Stolina M, Smith SY, Kostenuik PJ. Ominsky MS, et al. Among authors: pyrah i. Bone. 2011 Aug;49(2):162-73. doi: 10.1016/j.bone.2011.04.001. Epub 2011 Apr 9. Bone. 2011. PMID: 21497676

2

Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

Boyce RW, Varela A, Chouinard L, Bussiere JL, Chellman GJ, Ominsky MS, Pyrah IT. Boyce RW, et al. Among authors: pyrah it. Bone. 2014 Jul;64:314-25. doi: 10.1016/j.bone.2014.04.002. Epub 2014 Apr 13. Bone. 2014. PMID: 24727159

3

Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody.

Kostenuik PJ, Smith SY, Jolette J, Schroeder J, Pyrah I, Ominsky MS. Kostenuik PJ, et al. Among authors: pyrah i. Bone. 2011 Aug;49(2):151-61. doi: 10.1016/j.bone.2011.03.769. Epub 2011 Mar 30. Bone. 2011. PMID: 21457806

4

Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats.

Ominsky MS, Brown DL, Van G, Cordover D, Pacheco E, Frazier E, Cherepow L, Higgins-Garn M, Aguirre JI, Wronski TJ, Stolina M, Zhou L, Pyrah I, Boyce RW. Ominsky MS, et al. Among authors: pyrah i. Bone. 2015 Dec;81:380-391. doi: 10.1016/j.bone.2015.08.007. Epub 2015 Aug 8. Bone. 2015. PMID: 26261096 Free article.

5

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.

Taylor S, Ominsky MS, Hu R, Pacheco E, He YD, Brown DL, Aguirre JI, Wronski TJ, Buntich S, Afshari CA, Pyrah I, Nioi P, Boyce RW. Taylor S, et al. Among authors: pyrah i. Bone. 2016 Mar;84:148-159. doi: 10.1016/j.bone.2015.12.013. Epub 2015 Dec 22. Bone. 2016. PMID: 26721737 Free article.

6

Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys.

Ominsky MS, Boyd SK, Varela A, Jolette J, Felx M, Doyle N, Mellal N, Smith SY, Locher K, Buntich S, Pyrah I, Boyce RW. Ominsky MS, et al. Among authors: pyrah i. J Bone Miner Res. 2017 Apr;32(4):788-801. doi: 10.1002/jbmr.3036. Epub 2016 Dec 13. J Bone Miner Res. 2017. PMID: 27865001 Free article.

7

Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats.

Taylor S, Hu R, Pacheco E, Locher K, Pyrah I, Ominsky MS, Boyce RW. Taylor S, et al. Among authors: pyrah i. Bone Rep. 2018 Mar 15;8:95-103. doi: 10.1016/j.bonr.2018.03.002. eCollection 2018 Jun. Bone Rep. 2018. PMID: 29955627 Free PMC article.

8

Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody.

Boyce RW, Brown D, Felx M, Mellal N, Locher K, Pyrah I, Ominsky MS, Taylor S. Boyce RW, et al. Among authors: pyrah i. Bone Rep. 2018 Mar 3;8:90-94. doi: 10.1016/j.bonr.2018.03.001. eCollection 2018 Jun. Bone Rep. 2018. PMID: 29955626 Free PMC article.

9

Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats.

Nioi P, Taylor S, Hu R, Pacheco E, He YD, Hamadeh H, Paszty C, Pyrah I, Ominsky MS, Boyce RW. Nioi P, et al. Among authors: pyrah i. J Bone Miner Res. 2015 Aug;30(8):1457-67. doi: 10.1002/jbmr.2482. Epub 2015 May 22. J Bone Miner Res. 2015. PMID: 25678055 Free article.

10

Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study.

Chouinard L, Felx M, Mellal N, Varela A, Mann P, Jolette J, Samadfam R, Smith SY, Locher K, Buntich S, Ominsky MS, Pyrah I, Boyce RW. Chouinard L, et al. Among authors: pyrah i. Regul Toxicol Pharmacol. 2016 Nov;81:212-222. doi: 10.1016/j.yrtph.2016.08.010. Epub 2016 Aug 26. Regul Toxicol Pharmacol. 2016. PMID: 27569204 Free article. Review.

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