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459 results

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Long-Term outcomes after stress echocardiography in real world practice: five-year follow-up of the UK Evarest study.
Woodward W, Johnson CL, Krasner S, O'Driscoll J, McCourt A, Dockerill C, Balkhausen K, Chandrasekaran B, Firoozan S, Kardos A, Sabharwal N, Sarwar R, Senior R, Sharma R, Wong K, Augustine DX, Leeson P; EVAREST Investigators. Woodward W, et al. Eur Heart J Cardiovasc Imaging. 2024 Nov 12:jeae291. doi: 10.1093/ehjci/jeae291. Online ahead of print. Eur Heart J Cardiovasc Imaging. 2024. PMID: 39531637
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.
Yang Y, Jayaprakash D, Jhujh SS, Reynolds JJ, Chen S, Gao Y, Anand JR, Mutter-Rottmayer E, Ariel P, An J, Cheng X, Pearce KH, Blanchet SA, Nandakumar N, Zhou P, Fradet-Turcotte A, Stewart GS, Vaziri C. Yang Y, et al. Among authors: pearce kh. Nucleic Acids Res. 2024 Oct 24:gkae918. doi: 10.1093/nar/gkae918. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39445802
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Tse EG, Stashko MA, Li K, Norris-Drouin JL, Herring LE, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith CH, Couñago RM, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise MT, Willson TM, Popov KI, Pearce KH. Merten EM, et al. Among authors: pearce kh. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388272
Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells.
Uguen M, Shell DJ, Silva M, Deng Y, Li F, Szewczyk MM, Yang K, Zhao Y, Stashko MA, Norris-Drouin JL, Waybright JM, Beldar S, Rectenwald JM, Mordant AL, Webb TS, Herring LE, Arrowsmith CH, Ackloo S, Gygi SP, McGinty RK, Barsyte-Lovejoy D, Liu P, Halabelian L, James LI, Pearce KH, Frye SV. Uguen M, et al. Among authors: pearce kh. bioRxiv [Preprint]. 2024 Sep 28:2024.09.27.615363. doi: 10.1101/2024.09.27.615363. bioRxiv. 2024. PMID: 39386588 Free PMC article. Preprint.
A First-in-Class High-Throughput Screen to Discover Modulators of the Alternative Lengthening of Telomeres (ALT) Pathway.
Froney MM, Cook CR, Cadiz AM, Flinter KA, Ledeboer ST, Chan B, Burris LE, Hardy BP, Pearce KH, Wardell AC, Golitz BT, Jarstfer MB, Pattenden SG. Froney MM, et al. Among authors: pearce kh. ACS Pharmacol Transl Sci. 2024 Aug 13;7(9):2799-2819. doi: 10.1021/acsptsci.4c00251. eCollection 2024 Sep 13. ACS Pharmacol Transl Sci. 2024. PMID: 39296266
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity.
Ghoshal A, Asressu KH, Hossain MA, Brown PJ, Nandakumar M, Vala A, Merten EM, Sears JD, Law I, Burdick JE, Morales NL, Perveen S, Pearce KH, Popov KI, Moorman NJ, Heise MT, Willson TM. Ghoshal A, et al. Among authors: pearce kh. J Med Chem. 2024 Sep 26;67(18):16505-16532. doi: 10.1021/acs.jmedchem.4c01346. Epub 2024 Sep 5. J Med Chem. 2024. PMID: 39235978 Free PMC article.
459 results