Villegas S - Search Results

1

An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway.

Marín-Argany M, Rivera-Hernández G, Martí J, Villegas S. Marín-Argany M, et al. Among authors: villegas s. Biochem J. 2011 Jul 1;437(1):25-34. doi: 10.1042/BJ20101712. Biochem J. 2011. PMID: 21501114

2

Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.

Giménez-Llort L, Rivera-Hernández G, Marin-Argany M, Sánchez-Quesada JL, Villegas S. Giménez-Llort L, et al. Among authors: villegas s. MAbs. 2013 Sep-Oct;5(5):665-77. doi: 10.4161/mabs.25424. Epub 2013 Jun 20. MAbs. 2013. PMID: 23884018 Free PMC article.

3

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment.

Esquerda-Canals G, Marti J, Rivera-Hernández G, Giménez-Llort L, Villegas S. Esquerda-Canals G, et al. Among authors: villegas s. MAbs. 2013 Sep-Oct;5(5):660-4. doi: 10.4161/mabs.25428. Epub 2013 Jun 20. MAbs. 2013. PMID: 23884149 Free PMC article.

4

Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.

Rivera-Hernández G, Marin-Argany M, Blasco-Moreno B, Bonet J, Oliva B, Villegas S. Rivera-Hernández G, et al. Among authors: villegas s. MAbs. 2013 Sep-Oct;5(5):678-89. doi: 10.4161/mabs.25382. Epub 2013 Jun 19. MAbs. 2013. PMID: 23924802 Free PMC article.

5

A thermodynamic study of the third PDZ domain of MAGUK neuronal protein PSD-95 reveals a complex three-state folding behavior.

Murciano-Calles J, Martinez JC, Marin-Argany M, Villegas S, Cobos ES. Murciano-Calles J, et al. Among authors: villegas s. Biophys Chem. 2014 Jan;185:1-7. doi: 10.1016/j.bpc.2013.10.005. Epub 2013 Nov 2. Biophys Chem. 2014. PMID: 24295614

6

The impact of extra-domain structures and post-translational modifications in the folding/misfolding behaviour of the third PDZ domain of MAGUK neuronal protein PSD-95.

Murciano-Calles J, Marin-Argany M, Cobos ES, Villegas S, Martinez JC. Murciano-Calles J, et al. Among authors: villegas s. PLoS One. 2014 May 20;9(5):e98124. doi: 10.1371/journal.pone.0098124. eCollection 2014. PLoS One. 2014. PMID: 24845085 Free PMC article.

7

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.

Marin-Argany M, Güell-Bosch J, Blancas-Mejía LM, Villegas S, Ramirez-Alvarado M. Marin-Argany M, et al. Among authors: villegas s. Protein Sci. 2015 Nov;24(11):1829-40. doi: 10.1002/pro.2790. Epub 2015 Sep 7. Protein Sci. 2015. PMID: 26300552 Free PMC article.

8

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden.

Esquerda-Canals G, Roda AR, Martí-Clúa J, Montoliu-Gaya L, Rivera-Hernández G, Villegas S. Esquerda-Canals G, et al. Among authors: villegas s. J Alzheimers Dis. 2019;70(4):1069-1091. doi: 10.3233/JAD-190484. J Alzheimers Dis. 2019. PMID: 31306135

9

The interconversion between a flexible β-sheet and a fibril β-arrangement constitutes the main conformational event during misfolding of PSD95-PDZ3 domain.

Marin-Argany M, Candel AM, Murciano-Calles J, Martinez JC, Villegas S. Marin-Argany M, et al. Among authors: villegas s. Biophys J. 2012 Aug 22;103(4):738-47. doi: 10.1016/j.bpj.2012.07.029. Biophys J. 2012. PMID: 22947935 Free PMC article.

10

Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential.

Montoliu-Gaya L, Murciano-Calles J, Martinez JC, Villegas S. Montoliu-Gaya L, et al. Among authors: villegas s. Amyloid. 2017 Sep;24(3):167-175. doi: 10.1080/13506129.2017.1348347. Epub 2017 Jul 12. Amyloid. 2017. PMID: 28699800

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