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Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin.
Slater JL, Howard SJ, Sharp A, Goodwin J, Gregson LM, Alastruey-Izquierdo A, Arendrup MC, Warn PA, Perlin DS, Hope WW. Slater JL, et al. Among authors: perlin ds. Antimicrob Agents Chemother. 2011 Jul;55(7):3075-83. doi: 10.1128/AAC.01686-10. Epub 2011 Apr 18. Antimicrob Agents Chemother. 2011. PMID: 21502627 Free PMC article.
Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.
Park S, Kelly R, Kahn JN, Robles J, Hsu MJ, Register E, Li W, Vyas V, Fan H, Abruzzo G, Flattery A, Gill C, Chrebet G, Parent SA, Kurtz M, Teppler H, Douglas CM, Perlin DS. Park S, et al. Among authors: perlin ds. Antimicrob Agents Chemother. 2005 Aug;49(8):3264-73. doi: 10.1128/AAC.49.8.3264-3273.2005. Antimicrob Agents Chemother. 2005. PMID: 16048935 Free PMC article. Clinical Trial.
Multi-azole resistance in Aspergillus fumigatus.
Howard SJ, Webster I, Moore CB, Gardiner RE, Park S, Perlin DS, Denning DW. Howard SJ, et al. Among authors: perlin ds. Int J Antimicrob Agents. 2006 Nov;28(5):450-3. doi: 10.1016/j.ijantimicag.2006.08.017. Epub 2006 Oct 10. Int J Antimicrob Agents. 2006. PMID: 17034993
Serum differentially alters the antifungal properties of echinocandin drugs.
Paderu P, Garcia-Effron G, Balashov S, Delmas G, Park S, Perlin DS. Paderu P, et al. Among authors: perlin ds. Antimicrob Agents Chemother. 2007 Jun;51(6):2253-6. doi: 10.1128/AAC.01536-06. Epub 2007 Apr 9. Antimicrob Agents Chemother. 2007. PMID: 17420211 Free PMC article.
359 results