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Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin.
Slater JL, Howard SJ, Sharp A, Goodwin J, Gregson LM, Alastruey-Izquierdo A, Arendrup MC, Warn PA, Perlin DS, Hope WW. Slater JL, et al. Among authors: sharp a. Antimicrob Agents Chemother. 2011 Jul;55(7):3075-83. doi: 10.1128/AAC.01686-10. Epub 2011 Apr 18. Antimicrob Agents Chemother. 2011. PMID: 21502627 Free PMC article.
Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect.
Hope WW, Warn PA, Sharp A, Howard S, Kasai M, Louie A, Walsh TJ, Drusano GL, Denning DW. Hope WW, et al. Among authors: sharp a. Antimicrob Agents Chemother. 2006 Nov;50(11):3680-8. doi: 10.1128/AAC.00369-06. Epub 2006 Sep 5. Antimicrob Agents Chemother. 2006. PMID: 16954320 Free PMC article.
Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.
Warn PA, Sharp A, Morrissey G, Denning DW. Warn PA, et al. Among authors: sharp a. Int J Antimicrob Agents. 2010 Feb;35(2):146-51. doi: 10.1016/j.ijantimicag.2009.09.029. Epub 2009 Dec 16. Int J Antimicrob Agents. 2010. PMID: 20015618
Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts.
Howard SJ, Livermore J, Sharp A, Goodwin J, Gregson L, Alastruey-Izquierdo A, Perlin DS, Warn PA, Hope WW. Howard SJ, et al. Among authors: sharp a. Antimicrob Agents Chemother. 2011 Oct;55(10):4880-7. doi: 10.1128/AAC.00621-11. Epub 2011 Aug 1. Antimicrob Agents Chemother. 2011. PMID: 21807969 Free PMC article.
1,116 results