Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.
Raoul W, Feumi C, Keller N, Lavalette S, Houssier M, Behar-Cohen F, Combadière C, Sennlaub F.
Raoul W, et al. Among authors: combadiere c.
Ophthalmic Res. 2008;40(3-4):115-9. doi: 10.1159/000119860. Epub 2008 Apr 18.
Ophthalmic Res. 2008.
PMID: 18421223
Free PMC article.
We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid-bloated subretinal microglial cells rather than subretinal pigment epithelium deposits [Combadiere C, et al: J Clin Invest 2007;117:2920-2928]....
We demonstrate that the anatomical equivalent of the drusen-like appearance in these mice are lipid-bloated subretinal microglial cells rath …