Kubbutat MH - Search Results

1

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.

Schmidt S, Preu L, Lemcke T, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Schmidt S, et al. Among authors: kubbutat mh. Eur J Med Chem. 2011 Jul;46(7):2759-69. doi: 10.1016/j.ejmech.2011.03.065. Epub 2011 Apr 6. Eur J Med Chem. 2011. PMID: 21524503

2

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

Kunick C, Zeng Z, Gussio R, Zaharevitz D, Leost M, Totzke F, Schächtele C, Kubbutat MH, Meijer L, Lemcke T. Kunick C, et al. Among authors: kubbutat mh. Chembiochem. 2005 Mar;6(3):541-9. doi: 10.1002/cbic.200400099. Chembiochem. 2005. PMID: 15696597

3

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones.

Kunick C, Bleeker C, Prühs C, Totzke F, Schächtele C, Kubbutat MH, Link A. Kunick C, et al. Among authors: kubbutat mh. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2148-53. doi: 10.1016/j.bmcl.2006.01.071. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16464582

4

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.

Kohfeld S, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Kohfeld S, et al. Among authors: kubbutat mh. Eur J Med Chem. 2007 Nov-Dec;42(11-12):1317-24. doi: 10.1016/j.ejmech.2007.02.007. Epub 2007 Mar 1. Eur J Med Chem. 2007. PMID: 17448574

5

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.

Egert-Schmidt AM, Dreher J, Dunkel U, Kohfeld S, Preu L, Weber H, Ehlert JE, Mutschler B, Totzke F, Schächtele C, Kubbutat MH, Baumann K, Kunick C. Egert-Schmidt AM, et al. Among authors: kubbutat mh. J Med Chem. 2010 Mar 25;53(6):2433-42. doi: 10.1021/jm901388c. J Med Chem. 2010. PMID: 20170163

6

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Determann R, et al. Among authors: kubbutat mh. Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14. Eur J Med Chem. 2012. PMID: 22560627

7

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Dimova D, Iyer P, Vogt M, Totzke F, Kubbutat MH, Schächtele C, Laufer S, Bajorath J. Dimova D, et al. Among authors: kubbutat mh. J Med Chem. 2012 Dec 27;55(24):11067-71. doi: 10.1021/jm3014508. Epub 2012 Dec 11. J Med Chem. 2012. PMID: 23210446

8

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

Barbosa ML, Lima LM, Tesch R, Sant'Anna CM, Totzke F, Kubbutat MH, Schächtele C, Laufer SA, Barreiro EJ. Barbosa ML, et al. Among authors: kubbutat mh. Eur J Med Chem. 2014 Jan;71:1-14. doi: 10.1016/j.ejmech.2013.10.058. Epub 2013 Oct 31. Eur J Med Chem. 2014. PMID: 24269511

9

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.

Schlütke L, Immer M, Preu L, Totzke F, Schächtele C, Kubbutat MHG, Kunick C. Schlütke L, et al. Among authors: kubbutat mhg. Eur J Pharm Biopharm. 2018 May;126:89-94. doi: 10.1016/j.ejpb.2017.03.011. Epub 2017 Mar 15. Eur J Pharm Biopharm. 2018. PMID: 28315448

10

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.

Karatas M, Chaikuad A, Berger B, Kubbutat MHG, Totzke F, Knapp S, Kunick C. Karatas M, et al. Among authors: kubbutat mhg. Molecules. 2021 Mar 14;26(6):1611. doi: 10.3390/molecules26061611. Molecules. 2021. PMID: 33799460 Free PMC article.

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