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Small-molecule inhibitors of the PI3K signaling network.
McNamara CR, Degterev A. McNamara CR, et al. Among authors: degterev a. Future Med Chem. 2011 Apr;3(5):549-65. doi: 10.4155/fmc.11.12. Future Med Chem. 2011. PMID: 21526896 Free PMC article. Review.
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Miao B, et al. Among authors: degterev a. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. doi: 10.1073/pnas.1004522107. Epub 2010 Nov 1. Proc Natl Acad Sci U S A. 2010. PMID: 21041639 Free PMC article.
Akt and mTOR mediate programmed necrosis in neurons.
Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Liu Q, et al. Among authors: degterev a. Cell Death Dis. 2014 Feb 27;5(2):e1084. doi: 10.1038/cddis.2014.69. Cell Death Dis. 2014. PMID: 24577082 Free PMC article.
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M. Hrdinka M, et al. Among authors: degterev a. EMBO J. 2018 Sep 3;37(17):e99372. doi: 10.15252/embj.201899372. Epub 2018 Jul 19. EMBO J. 2018. PMID: 30026309 Free PMC article.
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Suebsuwong C, et al. Among authors: degterev a. Eur J Med Chem. 2020 Aug 15;200:112417. doi: 10.1016/j.ejmech.2020.112417. Epub 2020 May 15. Eur J Med Chem. 2020. PMID: 32505849 Free PMC article.
99 results